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CAMK1

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(Redirected fromCAMKI)

Protein-coding gene in humans
CAMK1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

4FG7,4FG8,4FG9,4FGB

Identifiers
AliasesCAMK1, CAMKI, calcium/calmodulin dependent protein kinase I, CaMKI-alpha, CaM kinase I alpha
External IDsOMIM:604998;MGI:1098535;HomoloGene:117458;GeneCards:CAMK1;OMA:CAMK1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CAMK1
Genomic location for CAMK1
Band3p25.3Start9,757,347bp[1]
End9,769,992bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CAMK1
Genomic location for CAMK1
Band6 E3|6 52.75 cMStart113,311,085bp[2]
End113,320,945bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal cortex

  • left adrenal cortex

  • right frontal lobe

  • nucleus accumbens

  • prefrontal cortex

  • caudate nucleus

  • monocyte

  • Amygdala

  • left uterine tube

  • putamen
Top expressed in
  • superior frontal gyrus

  • stroma of bone marrow

  • primary visual cortex

  • external carotid artery

  • dorsomedial hypothalamic nucleus

  • internal carotid artery

  • right kidney

  • arcuate nucleus

  • myocardium of ventricle

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8536

52163

Ensembl

ENSG00000134072

ENSMUSG00000030272

UniProt

Q14012

Q91YS8

RefSeq (mRNA)

NM_003656

NM_133926

RefSeq (protein)

NP_003647
NP_003647.1

NP_598687

Location (UCSC)Chr 3: 9.76 – 9.77 MbChr 6: 113.31 – 113.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase type 1 is anenzyme that in humans is encoded by theCAMK1gene.[5][6]

Calcium/calmodulin-dependentprotein kinase I isexpressed in manytissues and is a component of acalmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes thephosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000134072 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000030272 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995)."Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase".EMBO J.14 (15):3679–86.doi:10.1002/j.1460-2075.1995.tb00037.x.PMC 394442.PMID 7641687.
  6. ^ab"Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

Further reading

[edit]

External links

[edit]
PDB gallery
  • 1a06: CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
    1a06: CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
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