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CAMK4

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
CAMK4
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2W4O

Identifiers
AliasesCAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDsOMIM:114080;MGI:88258;HomoloGene:100780;GeneCards:CAMK4;OMA:CAMK4 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CAMK4
Genomic location for CAMK4
Band5q22.1Start111,223,653bp[1]
End111,494,886bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for CAMK4
Genomic location for CAMK4
Band18 B1|18 18.15 cMStart33,067,984bp[2]
End33,324,281bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • middle temporal gyrus

  • left testis

  • right testis

  • paraflocculus of cerebellum

  • ganglionic eminence

  • nucleus accumbens

  • superior frontal gyrus
Top expressed in
  • cerebellar cortex

  • superior frontal gyrus

  • thymus

  • primary visual cortex

  • lobe of cerebellum

  • seminiferous tubule

  • dentate gyrus of hippocampal formation granule cell

  • cerebellar vermis

  • spermatid

  • olfactory tubercle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

814

12326

Ensembl

ENSG00000152495

ENSMUSG00000038128

UniProt

Q16566

P08414
Q8BGR3

RefSeq (mRNA)

NM_001744
NM_001323374
NM_001323375
NM_001323376
NM_001323377

NM_009793

RefSeq (protein)

NP_001310303
NP_001310304
NP_001310305
NP_001310306
NP_001735

NP_033923

Location (UCSC)Chr 5: 111.22 – 111.49 MbChr 18: 33.07 – 33.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase type IV is anenzyme that in humans is encoded by theCAMK4gene.[5]

The product of this gene belongs to theserine/threonine protein kinase cluster, and to theCa2+/calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation inlymphocytes,neurons, andmale germ cells.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000152495 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000038128 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV".Genomics.4 (1):21–7.doi:10.1016/0888-7543(89)90309-1.PMID 2536634.
  6. ^"Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV".

Further reading

[edit]

External links

[edit]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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