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CACNB3

From Wikipedia, the free encyclopedia

Protein-coding gene in humans
CACNB3
Identifiers
AliasesCACNB3, CAB3, CACNLB3, calcium voltage-gated channel auxiliary subunit beta 3
External IDsOMIM:601958;MGI:103307;HomoloGene:20187;GeneCards:CACNB3;OMA:CACNB3 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CACNB3
Genomic location for CACNB3
Band12q13.12Start48,813,794bp[1]
End48,828,941bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CACNB3
Genomic location for CACNB3
Band15 F1|15 54.64 cMStart98,528,721bp[2]
End98,542,410bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • frontal pole

  • right uterine tube

  • right frontal lobe

  • right ovary

  • left ovary

  • right hemisphere of cerebellum

  • endothelial cell

  • prefrontal cortex

  • stromal cell of endometrium
Top expressed in
  • habenula

  • superior frontal gyrus

  • primary visual cortex

  • entorhinal cortex

  • dentate gyrus of hippocampal formation granule cell

  • perirhinal cortex

  • CA3 field

  • olfactory epithelium

  • lumbar spinal ganglion

  • external carotid artery
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

784

12297

Ensembl

ENSG00000167535

ENSMUSG00000003352

UniProt

P54284

P54285

RefSeq (mRNA)

NM_000725
NM_001206915
NM_001206916
NM_001206917

NM_001044741
NM_001286226
NM_007581
NM_001356543

RefSeq (protein)

NP_000716
NP_001193844
NP_001193845
NP_001193846

NP_001038206
NP_001273155
NP_031607
NP_001343472

Location (UCSC)Chr 12: 48.81 – 48.83 MbChr 15: 98.53 – 98.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Voltage-dependent L-type calcium channel subunit beta-3 is aprotein that in humans is encoded by theCACNB3gene.[5][6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000167535Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000003352Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J (Apr 1994). "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit".Eur J Biochem.220 (1):257–62.doi:10.1111/j.1432-1033.1994.tb18621.x.PMID 8119293.
  6. ^"Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit".

Further reading

[edit]

External links

[edit]
PDB gallery
  • 1vyt: BETA3 SUBUNIT COMPLEXED WITH AID
    1vyt: BETA3 SUBUNIT COMPLEXED WITH AID
  • 1vyu: BETA3 SUBUNIT OF VOLTAGE-GATED CA2+-CHANNEL
    1vyu: BETA3 SUBUNIT OF VOLTAGE-GATED CA2+-CHANNEL
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl:Chloride channel
H+:Proton channel
M+:CNG cation channel
M+:TRP cation channel
H2O (+solutes):Porin
Cytoplasm:Gap junction
By gating mechanism
Ion channel class
see alsodisorders


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