| Phorbol esters/diacylglycerol binding domain (C1 domain) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 C1 domain of PKC-delta (1ptr)Middle plane of the lipid bilayer - black dots. Boundary of the hydrocarbon core region - blue dots (cytoplasmic side). Layer of lipid phosphates - yellow dots. | |||||||||
| Identifiers | |||||||||
| Symbol | C1 | ||||||||
| Pfam | PF00130 | ||||||||
| InterPro | IPR002219 | ||||||||
| SMART | C1 | ||||||||
| PROSITE | PDOC00379 | ||||||||
| SCOP2 | 2cpk /SCOPe /SUPFAM | ||||||||
| OPM superfamily | 60 | ||||||||
| OPM protein | 1ptr | ||||||||
| CDD | cd00029 | ||||||||
| |||||||||
C1 domain (also known asphorbol esters/diacylglycerol binding domain) binds an important secondary messengerdiacylglycerol (DAG), as well as the analogousphorbol esters.[1] Phorbol esters can directly stimulateprotein kinase C, PKC.
Phorbol esters (such asPMA) are analogues of DAG and potenttumor promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family ofserine/threonine protein kinases, collectively known asprotein kinase C (PKC). Phorbol esters can directly stimulate PKC.
TheN-terminal region of PKC, known as C1, binds PMA and DAG in aphospholipid and zinc-dependent fashion.[2] The C1 region contains one or two copies of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PMA-binding.
The DAG/PMA-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.
AKAP13;ARAF;ARHGAP29;ARHGEF2;BRAF;CDC42BPA;CDC42BPB;CDC42BPG;CHN1;CHN2;CIT;CIC;DGKA;DGKB;DGKD;DGKE;DGKG;DGKH;DGKI;DGKK;DGKQ;DGKZ;GMIP;HMHA1;KSR1;KSR2;MYO9A;MYO9B;PDZD8;PRKCA;PRKCB1;PRKCD;PRKCE;PRKCG;PRKCH;PRKCI;PRKCN;PRKCQ;PRKCZ;PRKD1;PRKD2;PRKD3;RACGAP1;RAF1;RASGRP;RASGRP1;RASGRP2;RASGRP3;RASGRP4;RASSF1;RASSF5;ROCK1;ROCK2;STAC;STAC2;STAC3;TENC1;UNC13A;UNC13B;UNC13C;VAV1;VAV2;VAV3;