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| Trade names | Buphedrone |
| Routes of administration | Vaporization,insufflation,Intravenous injection,intramuscular injection,orally,rectal,buccal |
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| Pharmacokinetic data | |
| Excretion | Urine |
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| Formula | C11H15NO |
| Molar mass | 177.247 g·mol−1 |
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Buphedrone, also known asα-methylamino-butyrophenone (MABP), is astimulant of thephenethylamine andcathinonechemical classes that was firstsynthesized in 1928.[1] It is a synthetic analogue ofcathinone, a stimulant naturally occurring in thekhat plant. Like many other synthetic cathinones (e.g.mephedrone), it is also found in so called "legal highs" (sometimes also called "bath salts"), a class of designer drugs used to bypass legal restrictions.[2]
This substance is part of the cathinone family, which is considered to have the two relatives, namely phenethylamines (e.g. venlafaxin and more wider also including cocaine), and amphetamines in terms of how this substance is working at the human brain (that is, these substances are not activating postsynaptic receptors by themself, but are binding to specific receptors, which then, this receptors increases the concentration of endogenous monoamines in the human brain).
Buphedrone is a β-ketone and is related to the naturally occurring compoundscathinone andcathine. It is also related tomethamphetamine, differing by the β-ketone substituent (at the β-carbon) and anethyl group replacing themethyl group at the carbon at the α-position relative to theamine. Another name for buphedrone is phenylacetoethyl-methylamine.
Buphedrone as free base is very unstable; it is prone to dimerization like other α-amino ketones. Because of this, it is sold as various salts, with ahydrochloride being most common.
Buphedroneincreases spontaneous rodent locomotor activity,[3] potentiates the release ofdopamine fromdopaminergicnerve terminals in thebrain,[4] and causesappetite suppression. It also causes a possibly dangerous effect of decreasing subjective feeling of thirst. Though the specific effects and toxicity of buphedrone are not well studied,[5] in general it is expected to have overlapping effects with other synthetic cathinones.[6]
As of October 2015, buphedrone is a controlled substance in China.[7]
Buphedrone is anAnlage II controlled drug in Germany.
In the United States, buphedrone is considered a schedule 1 controlled substance as a positional isomer ofmephedrone.[8]
