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| Clinical data | |
|---|---|
| Trade names | Ambodryl, Ambrodil, Deserol |
| Other names | Bromodiphenhydramine; Bromdiphenhydramine |
| MedlinePlus | a682065 |
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | High |
| Protein binding | 96% |
| Metabolism | Mostlyhepatic (CYP-mediated), alsorenal |
| Eliminationhalf-life | 1 to 4 hours |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.003.854 |
| Chemical and physical data | |
| Formula | C17H20BrNO |
| Molar mass | 334.257 g·mol−1 |
| 3D model (JSmol) | |
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Bromazine, sold under the brand namesAmbodryl,Ambrodil, andDeserol among others, also known asbromodiphenhydramine, is anantihistamine andanticholinergic medication of theethanolamine class.[1][2][3][4][5] It is ananalogue ofdiphenhydramine with abrominesubstitution on one of thephenyl rings.[1][2]
Grignard reaction betweenphenylmagnesium bromide and para-bromobenzaldehyde [1122-91-4] (1) gives p-bromobenzhydrol [29334-16-5] (2). Halogenation withacetyl bromide in benzene solvent gives p-bromo-benzhydrylbromide [18066-89-2] (3). Finally, etherification withdeanol completed the synthesis of Bromazine (4).
Continuous and/or cumulative use ofanticholinergic medications, including first-generation antihistamines, is associated with higher risk forcognitive decline anddementia in elderly people.[8][9]
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