Protein encoded by the BSX gene
Brain-specific homeobox is aprotein that in humans is encoded by theBSX gene .[ 1]
Structure and expression pattern [ edit ] Bsx is an evolutionarily highly-conserved homeodomain-containing transcription factor that belongs to the ANTP-class.[ 2] telencephalic septum ,pineal gland , themammillary bodies andarcuate nucleus .[ 3]
Function in the hypothalamus [ edit ] In the hypothalamicarcuate nucleus , Bsx has been demonstrated to be necessary for normal expression levels of the twoorexigenic neuropeptides Agouti-related peptide andNeuropeptide Y .[ 4]
Function in the pineal gland [ edit ] In thepineal gland of the clawed frogXenopus circadian rhythm and controlsphotoreceptor cell differentiation .[ 5] zebrafish Bsx is required for normal development of all cell types within thepineal gland , includingmelatonin -releasing pinealocytes,photoreceptor cells and leftwards migrating parapineal cells,[ 6] brain asymmetry .[ 7]
^ "Entrez Gene: BSX brain-specific homeobox" .^ Ferrier, David E. K. (14 April 2016)."Evolution of Homeobox Gene Clusters in Animals: The Giga-Cluster and Primary vs. Secondary Clustering" .Frontiers in Ecology and Evolution .4 : 36.Bibcode :2016FrEEv...4...36F .doi :10.3389/fevo.2016.00036 hdl :10023/8685 ^ Cremona, M; Colombo, E; Andreazzoli, M; Cossu, G; Broccoli, V (January 2004). "Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus".Gene Expression Patterns .4 (1):47– 51.doi :10.1016/S1567-133X(03)00151-0 .PMID 14678827 . ^ Sakkou, M; Wiedmer, P; Anlag, K; Hamm, A; Seuntjens, E; Ettwiller, L; Tschöp, MH; Treier, M (June 2007)."A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior" .Cell Metabolism .5 (6):450– 63.doi :10.1016/j.cmet.2007.05.007 PMID 17550780 . ^ D'Autilia, S.; Broccoli, V.; Barsacchi, G.; Andreazzoli, M. (22 March 2010)."Xenopus Bsx links daily cell cycle rhythms and pineal photoreceptor fate" .Proceedings of the National Academy of Sciences .107 (14):6352– 6357.Bibcode :2010PNAS..107.6352D .doi :10.1073/pnas.1000854107 PMC 2852004 PMID 20308548 . ^ Schredelseker, Theresa; Driever, Wolfgang (1 July 2018)."Bsx controls pineal complex development" .Development .145 (13): dev163477.doi :10.1242/dev.163477 PMID 29945867 . ^ Duboc, Véronique; Dufourcq, Pascale; Blader, Patrick; Roussigné, Myriam (23 November 2015). "Asymmetry of the Brain: Development and Implications".Annual Review of Genetics .49 (1):647– 672.doi :10.1146/annurev-genet-112414-055322 .PMID 26442849 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
