Brain-specific angiogenesis inhibitor 3 is aprotein that in humans is encoded by theBAI3gene.[5][6]
BAI1, a p53-target gene, encodes brain-specificangiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.[7]
The adhesion GPCR BaI3 is an orphan receptor that has a longN-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)".Cytogenetics and Cell Genetics.79 (1–2):103–108.doi:10.1159/000134693.PMID9533023.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84 (1):23–33.doi:10.1016/j.ygeno.2003.12.004.PMID15203201.
