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Bone morphogenetic protein 10

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

BMP10
Identifiers
AliasesBMP10, entrez:27302, bone morphogenetic protein 10
External IDsOMIM:608748;MGI:1338820;HomoloGene:7644;GeneCards:BMP10;OMA:BMP10 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for BMP10
Genomic location for BMP10
Band2p13.3Start68,860,909bp[1]
End68,871,397bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for BMP10
Genomic location for BMP10
Band6|6 D1Start87,405,976bp[2]
End87,414,659bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cardiac muscle tissue of right atrium

  • right auricle of heart

  • right lobe of liver

  • tibialis anterior muscle

  • mucosa of ileum

  • left ventricle

  • gastric mucosa

  • placenta

  • gastrocnemius muscle

  • blood
Top expressed in
  • atrium

  • atrioventricular valve

  • primordial ventricle

  • bulbus cordis

  • myocardium of atrium

  • endocardial cushion

  • cardiac muscle tissue of atrium

  • CA3 field

  • perirhinal cortex

  • ventricle of the heart
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27302

12154

Ensembl

ENSG00000163217

ENSMUSG00000030046

UniProt

O95393

Q9R229

RefSeq (mRNA)

NM_014482

NM_009756

RefSeq (protein)

NP_055297

NP_033886

Location (UCSC)Chr 2: 68.86 – 68.87 MbChr 6: 87.41 – 87.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bone morphogenetic protein 10 (BMP10) is aprotein that in humans is encoded by theBMP10gene.[5][6]

BMP10 is a polypeptide belonging to theTGF-β superfamily ofproteins.[6] It is a novel protein that, unlike most otherBMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a largesequence homology with other BMP's in the TGF-β superfamily.

Further reading

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000163217Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000030046Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: bone morphogenetic protein 10".
  6. ^abNeuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily".Mech. Dev.80 (2):181–4.doi:10.1016/S0925-4773(98)00221-4.PMID 10072785.S2CID 15626081.

External links

[edit]
TGF beta superfamily of ligands
Ligand ofACVR orTGFBR
Ligand ofBMPR
TGF beta receptors
(Activin,BMP,family)
TGFBR1:
TGFBR2:
TGFBR3:
Transducers/SMAD
Ligand inhibitors
Coreceptors
Other
Type I
ALK1 (ACVRL1)
ALK2 (ACVR1A)
ALK3 (BMPR1A)
ALK4 (ACVR1B)
ALK5 (TGFβR1)
ALK6 (BMPR1B)
ALK7 (ACVR1C)
Type II
TGFβR2
BMPR2
ACVR2A (ACVR2)
ACVR2B
AMHR2 (AMHR)
Type III
TGFβR3 (β-glycan)
Unsorted


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