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| Names | |
|---|---|
| Other names Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider |
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| UNII | |
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| Properties | |
| C71H110N24O18S | |
| Molar mass | 1619.85 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Bombesin is a 14-amino acidpeptide[1] originally isolated from theskin of theEuropean fire-bellied toad (Bombina bombina)[2] byVittorio Erspameret al. and named after its source.[3] It has two knownhomologs inmammals calledneuromedin B andgastrin-releasing peptide. It stimulatesgastrin release fromG cells. It activates three differentG-protein-coupledreceptors known as BBR1, -2, and -3.[4] It also activates these receptors in thebrain. Together withcholecystokinin, it is the second major source ofnegative feedback signals that stop eating behaviour.[5]
Bombesin is also atumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, andneuroblastoma.[6]
TheanuranBB4 receptorhomologue is termedfrog BB4 (fBB4).[3] Iwabuchiet al. 2003 discovered achicken (Gallus domesticus) receptor which is homologous to both themammalian BB3 and fBB4 and so they named itchBRS-3.5.[3]
Erspamer 1988 finds bombesin has a similar effect on the chicken to ranatensin, unreliably increasing or decreasing blood pressure.[7]
