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Bisulepin

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Bisulepin
Clinical data
ATC code
Identifiers
  • (3E)-N,N-dimethyl-3-(thieno[2,3-c][2]benzothiepin-4(9H)-ylidene)propan-1-amine
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
CompTox Dashboard(EPA)
ECHA InfoCard100.024.867Edit this at Wikidata
Chemical and physical data
FormulaC17H19NS2
Molar mass301.47 g·mol−1
3D model (JSmol)
  • CN(C)CC\C=C1\c2ccsc2SCc2ccccc12

Bisulepin is strong and relatively selectiveantihistamine (H1 antagonist) withhypnotic,antiadrenergic and very weakanticholinergic andantiserotonergic effects. Bisulepin is marketed in theCzech Republic andSlovakia under the trademarkDithiaden as tablets and injections.

The registered active form is thetrans- (i.e.E-) isomer.[1][2]

See also

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References

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  1. ^Polívka Z, Rajšner M, Metyš J, Holubek J, Svátek E, Ryska M, Protiva M (1983). "Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds".Collection of Czechoslovak Chemical Communications.48 (2):623–641.doi:10.1135/cccc19830623.
  2. ^Pharmacopoea Bohemoslovenica 4 (1987), vol. 2, p. 132 states that Bisulepinium chloratum (bisulepinium chloride) istrans-[3-(4,9-dihydro-thieno[2,3-c][2]benzithiepin-4-yliden)propyl]dimethylamoniumchlorid (Czech). Thecis- isomer is considered as an impurity, max. amount 2.0 %.

External links

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Benzimidazoles(*)
Diarylmethanes
Ethylenediamines
Tricyclics
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Fortopical use
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