Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Biophysics

From Wikipedia, the free encyclopedia
Interdisciplinary science
Part of aseries on
Physics

Biophysics is an interdisciplinary science that applies approaches and methods traditionally used inphysics to studybiological phenomena.[1][2][3][4]

Overview

[edit]
Aribosome is abiological machine.Protein domain dynamics can only be seen byneutron spin echo spectroscopy

Molecular biophysics typically addresses biological questions similar to those inbiochemistry andmolecular biology, seeking to find the physical underpinnings of biomolecular phenomena. Scientists in this field conduct research concerned with understanding the interactions between the various systems of a cell, including the interactions betweenDNA,RNA andprotein biosynthesis, as well as how these interactions are regulated. A great variety of techniques are used to answer these questions.

Biophysics covers all scales ofbiological organization, frommolecular toorganismic andpopulations. Biophysical research shares significant overlap withbiochemistry,molecular biology,physical chemistry,physiology,nanotechnology,bioengineering,computational biology,biomechanics,developmental biology andsystems biology.Fluorescent imaging techniques, as well aselectron microscopy,x-ray crystallography,NMR spectroscopy,atomic force microscopy (AFM) andsmall-angle scattering (SAS).

Small-angle X-ray scattering andsmall-angle neutron scattering (SAXS/SANS) are often used to visualize structures of biological significance.Protein dynamics can be observed byneutron spin echo spectroscopy.Conformational changes in structure can be measured using techniques such asdual polarisation interferometry,circular dichroism,SAXS andSANS. Direct manipulation of molecules usingoptical tweezers orAFM, can also be used to monitor biological events where forces and distances are at the nanoscale. Molecular biophysicists often consider complex biological events as systems of interacting entities which can be understood e.g. throughstatistical mechanics,thermodynamics andchemical kinetics. By drawing knowledge and experimental techniques from a wide variety of disciplines, biophysicists are often able to directly observe, model or even manipulate the structures and interactions of individualmolecules or complexes of molecules.

Kinesin usesprotein domain dynamics onnanoscales to "walk" along amicrotubule.

Medical physics, a branch of biophysics, is any application ofphysics tomedicine orhealthcare, ranging fromradiology tomicroscopy andnanomedicine. For example, physicistRichard Feynman theorized about the future ofnanomedicine. He wrote about the idea of amedical use forbiological machines (seenanomachines). Feynman andAlbert Hibbs suggested that certain repair machines might one day be reduced in size to the point that it would be possible to (as Feynman put it) "swallow the doctor". The idea was discussed in Feynman's 1959 essayThere's Plenty of Room at the Bottom.[5]

The termbiophysics is also regularly used in academia[who?] to indicate the study of thephysical quantities (e.g.electric current,temperature,stress,entropy) in biological systems. Otherbiological sciences also perform research on the biophysical properties of living organisms includingmolecular biology,cell biology,chemical biology, andbiochemistry.In addition to traditional (i.e. molecular and cellular) biophysical topics likestructural biology orenzyme kinetics, modern biophysics encompasses an extraordinarily broad range of research, frombioelectronics toquantum biology involving both experimental and theoretical tools. It is becoming increasingly common[4] for biophysicists to apply the models and experimental techniques derived fromphysics, as well asmathematics andstatistics, to larger systems such astissues,organs,[6]populations[7] andecosystems. Biophysical models are used extensively in the study of electrical conduction in singleneurons, as well as neural circuit analysis in both tissue and whole brain.[citation needed]

History

[edit]

The studies ofLuigi Galvani (1737–1798) laid groundwork for the later field of biophysics. Some of the earlier studies in biophysics were conducted in the 1840s by a group known as the Berlin school of physiologists. Among its members were pioneers such asHermann von Helmholtz,Ernst Heinrich Weber,Carl F. W. Ludwig, andJohannes Peter Müller.[8]

The termbiophysics was originally introduced byKarl Pearson in 1892.[9][10]William T. Bovie (1882–1958) is credited as a leader of the field's further development in the mid-20th century. He was a leader in developingelectrosurgery.

The popularity of the field rose when the bookWhat Is Life? byErwin Schrödinger was published.[citation needed] Since 1957, biophysicists have organized themselves into theBiophysical Society which now has about 9,000 members over the world.[11]

Some authors such asRobert Rosen criticize biophysics on the ground that the biophysical method does not take into account the specificity of biological phenomena.[12]

Focus as a subfield

[edit]

While some colleges and universities have dedicated departments of biophysics, usually at the graduate level, many do not have university-level biophysics departments, instead having groups in related departments such asbiochemistry,cell biology,chemistry,computer science,engineering,mathematics,medicine,molecular biology,neuroscience,pharmacology,physics, andphysiology. Depending on the strengths of a department at a university differing emphasis will be given to fields of biophysics. What follows is a list of examples of how each department applies its efforts toward the study of biophysics. This list is hardly all inclusive. Nor does each subject of study belong exclusively to any particular department. Each academic institution makes its own rules and there is much overlap between departments.[citation needed]

Manybiophysical techniques are unique to this field. Research efforts in biophysics are often initiated by scientists who were biologists, chemists or physicists by training.

See also

[edit]

References

[edit]
  1. ^"Biophysics | science".Encyclopedia Britannica. Retrieved2018-07-26.
  2. ^Zhou HX (March 2011)."Q&A: What is biophysics?".BMC Biology.9 13.doi:10.1186/1741-7007-9-13.PMC 3055214.PMID 21371342.
  3. ^"the definition of biophysics".www.dictionary.com. Retrieved2018-07-26.
  4. ^abKuba, Jaroslav (2025).Biophysics: Foundations, Problems, and Solutions. San Diego, CA: Academic Press (Elsevier).
  5. ^Feynman RP (December 1959)."There's Plenty of Room at the Bottom". Archived fromthe original on 2010-02-11. Retrieved2017-01-01.
  6. ^Sahai, Erik; Trepat, Xavier (July 2018). "Mesoscale physical principles of collective cell organization".Nature Physics.14 (7):671–682.Bibcode:2018NatPh..14..671T.doi:10.1038/s41567-018-0194-9.hdl:2445/180672.ISSN 1745-2481.S2CID 125739111.
  7. ^Popkin, Gabriel (2016-01-07)."The physics of life".Nature News.529 (7584):16–18.Bibcode:2016Natur.529...16P.doi:10.1038/529016a.PMID 26738578.
  8. ^Franceschetti DR (15 May 2012).Applied Science. Salem Press Inc. p. 234.ISBN 978-1-58765-781-8.
  9. ^Pearson, Karl (1892).The Grammar of Science. p. 470.
  10. ^Roland Glaser.Biophysics: An Introduction. Springer; 23 April 2012.ISBN 978-3-642-25212-9.
  11. ^Rosen J, Gothard LQ (2009).Encyclopedia of Physical Science. Infobase Publishing. p. 4 9.ISBN 978-0-8160-7011-4.
  12. ^Longo G, Montévil M (2012-01-01)."The Inert vs. the Living State of Matter: Extended Criticality, Time Geometry, Anti-Entropy - An Overview".Frontiers in Physiology.3: 39.doi:10.3389/fphys.2012.00039.PMC 3286818.PMID 22375127.

Sources

[edit]
Library resources about
Biophysics

External links

[edit]
AtWikiversity, you can learn more and teach others aboutBiophysics at theDepartment of Biophysics
Wikimedia Commons has media related toBiophysics.
Divisions
Approaches
Classical
Modern
Interdisciplinary
Related
See also
Biology
Overview
Chemical basis
Cells
Genetics
Evolution
Diversity
Plant form
and function
Animal form
and function
Ecology
Research
methods
Laboratory
techniques
Field techniques
Branches
Glossaries
International
National
Other
Retrieved from "https://en.wikipedia.org/w/index.php?title=Biophysics&oldid=1323284438"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp