It is located mainly inadipose tissue and is involved in the regulation of lipolysis andthermogenesis. Some β3agonists have demonstratedantistress effects in animal studies, suggesting it also has a role in the central nervous system (CNS). β3 receptors are found in the gallbladder, urinary bladder, and inbrown adipose tissue. Their role in gallbladder physiology is unknown, but they are thought to play a role in lipolysis and thermogenesis in brown fat. In the urinary bladder it is thought to cause relaxation of the bladder and prevention of urination.[8]
^Rang, H. P. (2003).Pharmacology. Edinburgh: Churchill Livingstone.ISBN0-443-07145-4. Page 163
^Sawa M, Harada H (2006). "Recent Developments in the Design of Orally Bioavailable β3-Adrenergic Receptor Agonists".Current Medicinal Chemistry.13 (1):25–37.doi:10.2174/092986706775198006.PMID16457637.
^Rozec B, Erfanian M, Laurent K, Trochu JN, Gauthier C (2009). "Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart".J Am Coll Cardiol.53 (17):1532–8.doi:10.1016/j.jacc.2008.11.057.PMID19389564.
^Edmondson SD, Zhu C, Kar NF, Di Salvo J, Nagabukuro H, Sacre-Salem B, Dingley, Berger R, Goble SD, Morriello G, Harper B, Moyes CR, Shen DM, Wang L, Ball R, Fitzmaurice A, Frenkl T, Gichuru LN, Ha S, Hurley AL, Jochnowitz N, Levorse D, Mistry S, Miller RR, Ormes J, Salituro GM, Sanfiz A, Stevenson AS, Villa K, Zamlynny B, Green S, Struthers M, Weber AE (January 2016). "Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder".Journal of Medicinal Chemistry.59 (2):609–23.doi:10.1021/acs.jmedchem.5b01372.PMID26709102.
^Consoli D, Leggio GM, Mazzola C, Micale V, Drago F (November 2007). "Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?".European Journal of Pharmacology.573 (1–3):139–47.doi:10.1016/j.ejphar.2007.06.048.PMID17669397.
^Overstreet DH, Stemmelin J, Griebel G (June 2008). "Confirmation of antidepressant potential of the selective β3 adrenoceptor agonist amibegron in an animal model of depression".Pharmacology Biochemistry and Behavior.89 (4):623–6.doi:10.1016/j.pbb.2008.02.020.PMID18358519.S2CID35026036.
^Fu L, Isobe K, Zeng Q, Suzukawa K, Takekoshi K, Kawakami Y (2008). "The effects of beta(3)-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-alpha expressions in adipose tissues of obese diabetic KKAy mice".European Journal of Pharmacology.584 (1):202–6.doi:10.1016/j.ejphar.2008.01.028.PMID18304529.
^abcCandelore MR, Deng L, Tota L, Guan XM, Amend A, Liu Y, Newbold R, Cascieri MA, Weber AE (August 1999). "Potent and selective human beta(3)-adrenergic receptor antagonists".The Journal of Pharmacology and Experimental Therapeutics.290 (2):649–55.PMID10411574.
^Hicks A, McCafferty GP, Riedel E, Aiyar N, Pullen M, Evans C, Luce TD, Coatney RW, Rivera GC, Westfall TD, Hieble JP (October 2007). "GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog".The Journal of Pharmacology and Experimental Therapeutics.323 (1):202–9.doi:10.1124/jpet.107.125757.PMID17626794.S2CID19281697.
^Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes".Mol. Pharmacol.49 (1):7–14.PMID8569714.
Granneman JG, Lahners KN, Rao DD (1993). "Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block".Mol. Pharmacol.42 (6):964–70.PMID1336117.
Emorine LJ, Marullo S, Briend-Sutren MM, Patey G, Tate K, Delavier-Klutchko C, Strosberg AD (1989). "Molecular characterization of the human beta 3-adrenergic receptor".Science.245 (4922):1118–21.Bibcode:1989Sci...245.1118E.doi:10.1126/science.2570461.PMID2570461.
Guan XM, Amend A, Strader CD (1995). "Determination of structural domains for G protein coupling and ligand binding in beta 3-adrenergic receptor".Mol. Pharmacol.48 (3):492–8.PMID7565630.
Rodriguez M, Carillon C, Coquerel A, Le Fur G, Ferrara P, Caput D, Shire D (1995). "Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain".Brain Res. Mol. Brain Res.29 (2):369–75.doi:10.1016/0169-328X(94)00274-I.PMID7609625.
Dib A, Adélaïde J, Chaffanet M, Imbert A, Le Paslier D, Jacquemier J, Gaudray P, Theillet C, Birnbaum D, Pébusque MJ (1995). "Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma".Oncogene.10 (5):995–1001.PMID7898940.
Mahmoudian M (1994). "The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study".Journal of Molecular Graphics.12 (1):22–8, 34.doi:10.1016/0263-7855(94)80004-9.PMID8011597.
Wilkie TM, Chen Y, Gilbert DJ, Moore KJ, Yu L, Simon MI, Copeland NG, Jenkins NA (1994). "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors".Genomics.18 (2):175–84.doi:10.1006/geno.1993.1452.PMID8288218.
Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Oga T, Ueda H, Shintani M, Fukuda M, Ogihara T (1996). "Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain".Diabetologia.39 (3):349–52.doi:10.1007/BF00418352.PMID8721782.S2CID24270803.
Higashi K, Ishikawa T, Ito T, Yonemura A, Shige H, Nakamura H (1997). "Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese".Biochem. Biophys. Res. Commun.232 (3):728–30.doi:10.1006/bbrc.1997.6339.PMID9126344.
Hoffstedt J, Poirier O, Thörne A, Lönnqvist F, Herrmann SM, Cambien F, Arner P (1999). "Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function".Diabetes.48 (1):203–5.doi:10.2337/diabetes.48.1.203.PMID9892244.
Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A (1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis".Nat. Genet.22 (3):239–47.doi:10.1038/10297.PMID10391210.S2CID4636523.
Kimura K, Sasaki N, Asano A, Mizukami J, Kayahashi S, Kawada T, Fushiki T, Morimatsu M, Yoshida T, Saito M (2000). "Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes".Horm. Metab. Res.32 (3):91–6.doi:10.1055/s-2007-978597.PMID10786926.S2CID260166451.
"β3-adrenoceptor".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 30 December 2014. Retrieved25 November 2008.
