Beraprost

Clinical data
Trade names	Dorner
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	B01AC19 (WHO)
Pharmacokinetic data
Bioavailability	50–70%
Metabolism	Unknown
Eliminationhalf-life	35–40 minutes
Identifiers
IUPAC name 4-{(1R,2R,3aS,8bS)-2-Hydroxy-1-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl}butanoic acid
CAS Number	88430-50-6 Y88475-69-8
PubChemCID	6917951
IUPHAR/BPS	1967
ChemSpider	5293169 Y
UNII	35E3NJJ4O6
ChEBI	CHEBI:135633
ChEMBL	ChEMBL1207745 N
CompTox Dashboard(EPA)	DTXSID7049136
Chemical and physical data
Formula	C24H30O5
Molar mass	398.499 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC#CCC(C)[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1C3=CC=CC(=C3O2)CCCC(=O)O)O)O
InChI InChI=1S/C24H30O5/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28)/b13-12+/t15?,17-,19+,20+,21-,23-/m0/s1 Y Key:CTPOHARTNNSRSR-APJZLKAGSA-N Y
NY (what is this?)  (verify)

Beraprost is a pharmaceutical drug used in several Asian countries, including Japan and South Korea, as avasodilator and antiplatelet agent.^[1] It is classified as aprostacyclin analog.^[1][2]

It has been studied for the treatment ofpulmonary hypertension and for use in avoidingreperfusion injury.

As an analog of prostacyclin PGI₂, beraprost affectsvasodilation, which in turn lowersblood pressure. Beraprost also inhibitsplatelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined.

Beraprost is administered orally as a pill available in strength of 20 mcg. Dose ranges from 60 to 180 mcg in divided doses after meals.

• Prostaglandins
• Alkyne derivatives
• Alkene derivatives
• Secondary alcohols

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