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Benzotript

From Wikipedia, the free encyclopedia
Cholecystokinin antagonist

Pharmaceutical compound
Benzotript
Clinical data
Other namesBenzotrypt; CR-501;N-(p-Chlorobenzoyl)-L-tryptophan;N-(4-Chlorobenzoyl)-L-tryptophan;N-[(4-Chlorophenyl)carbonyl]tryptophan
Identifiers
  • (2S)-2-[(4-chlorobenzoyl)amino]-3-(1H-indol-3-yl)propanoic acid
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.049.528Edit this at Wikidata
Chemical and physical data
FormulaC18H15ClN2O3
Molar mass342.78 g·mol−1
3D model (JSmol)
  • C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)C3=CC=C(C=C3)Cl
  • InChI=1S/C18H15ClN2O3/c19-13-7-5-11(6-8-13)17(22)21-16(18(23)24)9-12-10-20-15-4-2-1-3-14(12)15/h1-8,10,16,20H,9H2,(H,21,22)(H,23,24)/t16-/m0/s1
  • Key:QJERBBQXOMUURJ-INIZCTEOSA-N

Benzotript (INNTooltip International Nonproprietary Name), also known asN-(p-chlorobenzoyl)-L-tryptophan, is amuscle relaxant that inhibitsgastricsecretion and was never marketed.[1][2] It is atryptaminederivative and theN-(4-chlorobenzoyl)analogue of theamino acidtryptophan.[1] Similarly toproglumide (N2-benzoyl-N,N-dipropyl-α-glutamine), the drug acts as acompetitive andnon-selectivecholecystokinin receptor antagonist.[2][3] Other morepotent tryptophan derivatives have also been developed as cholecystokinin (CCK) antagonists.[2]

References

[edit]
  1. ^abElks J (2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1262.ISBN 978-1-4757-2085-3. Retrieved8 October 2024.
  2. ^abcHerranz R (September 2003). "Cholecystokinin antagonists: pharmacological and therapeutic potential".Med Res Rev.23 (5):559–605.doi:10.1002/med.10042.PMID 12789687.
  3. ^Maton PN, Jensen RT, Gardner JD (January 1986). "Cholecystokinin antagonists".Horm Metab Res.18 (1):2–9.doi:10.1055/s-2007-1012212.PMID 2419234.
Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
Cyclized tryptamines
Isotryptamines
Related compounds


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