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Benzomorphan

From Wikipedia, the free encyclopedia
Benzomorphan
Names
IUPAC name
6,7-Benzomorphan
Other names
  • 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine<
  • 10-Azatricyclo[7.3.1.0~2,7~]trideca-2,4,6-triene
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C12H15N/c1-2-4-12-9(3-1)7-11-8-10(12)5-6-13-11/h1-4,10-11,13H,5-8H2 ☒N
    Key: NSLKFRGZLUIUKO-UHFFFAOYSA-N ☒N
  • InChI=1/C12H15N/c1-2-4-12-9(3-1)7-11-8-10(12)5-6-13-11/h1-4,10-11,13H,5-8H2
    Key: NSLKFRGZLUIUKO-UHFFFAOYAF
  • C1CNC2CC1C3=CC=CC=C3C2
Properties
C12H15N
Molar mass173.259 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Benzomorphan is achemical compound that is the base for a series ofdrugs which variably act on thesigma receptors andκ-opioid receptors, including the following compounds:

Some of these agents are used asanalgesics, includingpentazocine,phenazocine,dezocine, andeptazocine.[7][8]

See also

[edit]

References

[edit]
  1. ^Yokoyama N, Almaula PI, Block FB, Granat FR, Gottfried N, Hill RT, McMahon EH, Munch WF, Rachlin H, Saelens JK, Siegel MG, Tomaselli HC, Clarke FH. Syntheses, analgetic activity, and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives. J Med Chem. 1979 May;22(5):537-53. doi: 10.1021/jm00191a016. PMID: 37335.
  2. ^Yokoyama, N., Block, F. B., Clarke, F. H. (May 1970). "1,2,3,4,5,6-Hexahydro-6-phenyl-2,6-methano-3-benzazocines. II". Journal of Medicinal Chemistry. 13 (3): 488–492. doi:10.1021/jm00297a034.
  3. ^Castañer, J., Paton, D. M. (1978)."ID-1229".Drugs of the Future.3 (4): 298.doi:10.1358/dof.1978.003.04.65215.ISSN 0377-8282. Retrieved21 October 2025.
  4. ^Yamamoto H, Saito C, Inaba S, Inukai T, Kobayashi K (May 1975). "The synthesis and pharmacology of a new analgesic, ID-1229".Arzneimittel-Forschung.25 (5):795–801.doi:10.1002/chin.197534266.PMID 1242327.
  5. ^Yamamoto, H., Saito, C., Inaba, S., Inukai, T., Kobayashi, K., Fukumaru, T., Koga, Y., Homma, T., Asami, Y. (26 August 1975)."ChemInform Abstract: THE SYNTHESIS AND PHARMACOLOGY OF A NEW ANALGESIC, ID‐1229".Chemischer Informationsdienst.6 (34) chin.197534266.doi:10.1002/chin.197534266.ISSN 2199-2924 0009-2975, 2199-2924. Retrieved21 October 2025.{{cite journal}}:Check|issn= value (help)
  6. ^Parenti C, Turnaturi R, Aricò G, Marrazzo A, Prezzavento O, Ronsisvalle S, Scoto GM, Ronsisvalle G, Pasquinucci L. Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. Life Sci. 2012 Jun 27;90(25-26):957-61. doi: 10.1016/j.lfs.2012.04.041. Epub 2012 May 11. PMID: 22580287.
  7. ^Kar, Ashutosh (2005).Medicinal Chemistry - Google Books.ISBN 978-81-224-1565-0.
  8. ^Cittern PA, Kapoor VK, Parfitt RT (October 1986). "Preparation and analgesic activity of (−)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines".Journal of Medicinal Chemistry.29 (10):1929–33.doi:10.1021/jm00160a022.PMID 2876100.
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