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| Clinical data | |
|---|---|
| Trade names | Tiadipona(ES) |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral (tablets) |
| ATC code | |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Eliminationhalf-life | 2–4 hours |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
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| ChemSpider |
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| UNII | |
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| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.123.659 |
| Chemical and physical data | |
| Formula | C17H16N2OS |
| Molar mass | 296.39 g·mol−1 |
| 3D model (JSmol) | |
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Bentazepam[1] (also known asThiadipone,Tiadipona) is athienodiazepine which is abenzodiazepine analog.[2]
It possessesanxiolytic,anticonvulsant,sedative andskeletal muscle relaxant properties.Peak plasma rates are achieved in around 2,5 hours after oral administration.[3] The elimination half-life is between approximately 2–4 hours.[2][4] Bentazepam is effective as an anxiolytic.
A severebenzodiazepine overdose with bentazepam may result in coma and respiratory failure.[5] Adverse effects include dry mouth,somnolence,asthenia,dyspepsia,constipation,nausea[6] and drug-inducedlymphocytic colitis has been associated with bentazepam.[7][8] Severe liver damage and hepatitis has also been associated with bentazepam.[9][10][11] Whilst liver failure from bentazepam is considered to be rare, liver function monitoring has been recommended for all patients taking bentazepam.[12]
