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Benoxathian

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Benoxathian
Names

IUPAC name N-(2,3-Dihydro-1,4-benzoxathiin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine
Identifiers
CAS Number	92642-94-9
3D model (JSmol)	Interactive image
ChemSpider	2235
PubChem CID	2325
CompTox Dashboard(EPA)	DTXSID10919033
InChI InChI=1S/C19H23NO4S/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14/h3-9,14,20H,10-13H2,1-2H3 Key: QAUVAHYHKLRJCQ-UHFFFAOYSA-N InChI=1/C19H23NO4S/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14/h3-9,14,20H,10-13H2,1-2H3 Key: QAUVAHYHKLRJCQ-UHFFFAOYAX
SMILES COC1=C(C(=CC=C1)OC)OCCNCC2CSC3=CC=CC=C3O2
Properties
Chemical formula	C₁₉H₂₃NO₄S
Molar mass	361.46 g·mol⁻¹
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

Benoxathian is anα₁-adrenergic receptor antagonist.^[1] It was studied in animals for itsantihypertensive (blood pressure lowering) effects in the 1980s.^[2]

^Nagayasu, K; Kitaichi, M; Nishitani, N; Asaoka, N; Shirakawa, H; Nakagawa, T; Kaneko, S (2013)."Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: High potency of milnacipran in the augmentation of serotonin release".The International Journal of Neuropsychopharmacology.16 (10):2295–306.doi:10.1017/S1461145713000771.PMID 23920436.
^Massi, M.; Venturi, F.; Brasili, L.; Melchiorre, C. (1986). "Hypotensive effect in dogs and rats of intravenous injections of the alpha 1-adrenoreceptor antagonist benoxathian".Pharmacological Research Communications.18 (9):813–829.doi:10.1016/0031-6989(86)90132-3.PMID 2879293.