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| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| ChemSpider |
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| UNII | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.023.340 |
| Chemical and physical data | |
| Formula | C17H15NO5 |
| Molar mass | 313.309 g·mol−1 |
| 3D model (JSmol) | |
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 N Y (what is this?) (verify) | |
Benorilate (INN), orbenorylate, is anester-linkedcodrug ofaspirin withparacetamol. It is used as ananti-inflammatory andantipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns aboutReye syndrome.[1]
Acetylsalicoyl chloride (1)condenses with paracetamol (2) to give benorilate (3).[2][3][4][5]
Alkaline hydrolysis of the acetyl ester moiety of benorilate yields another pharmaceutical,acetaminosalol (phenetsal).[6]
| pyrazolones / pyrazolidines | |
|---|---|
| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
|
| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
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