Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Benidipine

From Wikipedia, the free encyclopedia
Antihypertensive drug of the calcium channel blocker class
Pharmaceutical compound
Benidipine
Skeletal formula of benidipine
Ball-and-stick model of the benidipine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
By mouth
ATC code
Identifiers
  • O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC28H31N3O6
Molar mass505.571 g·mol−1
3D model (JSmol)
  • [O-][N+](=O)c1cccc(c1)[C@@H]4C(/C(=O)OC)=C(\N\C(=C4\C(=O)O[C@@H]3CCCN(Cc2ccccc2)C3)C)C
  • InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1 ☒N
  • Key:QZVNQOLPLYWLHQ-ZEQKJWHPSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Benidipine is a dihydropyridine calcium channel blocker for the treatment ofhigh blood pressure (hypertension). It is a tripleL-,T-, andN-typecalcium channel blocker. It is reno- and cardioprotective.

It was patented in 1981 and approved for medical use in 1991.[1]

Dosing

[edit]

Benidipine is dosed as 2–8 mg once daily.[2]

Mechanism

[edit]

Benidipine is acalcium channel blocker.

Benidipine has additionally been found to act as anantagonist of themineralocorticoid receptor, or as anantimineralocorticoid.[3]

Names

[edit]

Other names include Benidipinum or benidipine hydrochloride.

Benidipine is sold as Coniel by Kyowa Hakko Kogyo.

Benidipine is initially licensed for use in Japan and selectedSoutheast Asian countries and later in Turkey, where it is sold as 4 mg tablets.

References

[edit]
  1. ^Fischer J, Ganellin CR (2006).Analogue-based Drug Discovery. John Wiley & Sons. p. 465.ISBN 9783527607495.
  2. ^Hi-Eisai Pharmaceutical, Inc."Coniel (benidipine) package insert (Philippines)".MIMS Philippines. CMPMedica. Archived fromthe original on 2019-12-14. Retrieved2008-03-31.
  3. ^Luther JM (September 2014)."Is there a new dawn for selective mineralocorticoid receptor antagonism?".Current Opinion in Nephrology and Hypertension.23 (5):456–61.doi:10.1097/MNH.0000000000000051.PMC 4248353.PMID 24992570.
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
MRTooltip Mineralocorticoid receptor
Agonists
Antagonists
Retrieved from "https://en.wikipedia.org/w/index.php?title=Benidipine&oldid=1264173084"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp