Discussing the role ofprostaglandins in the body, Samuelsson explained, "It's a control system for the cells that participates in many biological functions. There are endless possibilities of manipulating this system in drug development."
His research interests were originally incholesterol metabolism with importance to reaction mechanisms. Following the structural work on prostaglandins along with Sune Bergström he was interested mainly in the transformation products ofarachidonic acid. This has led to the identification ofendoperoxides,thromboxanes and theleukotrienes, and his group has chiefly been involved in studying thechemistry,biochemistry andbiology of these compounds and their function in biological control systems. This research has implications in numerous clinical areas, especially inthrombosis,inflammation, andallergy.
This field has grown enormously since those days. Between 1981 and 1995, about 3,000 papers per year were published that specifically used the expression "prostaglandins," or related terms such as "prostacyclins," "leukotrienes," and "thromboxanes," in their labels and titles.
Samuelsson had served as a director on the boards ofPharmacia AB,NicOx SA, andSchering AG, and was an advisor to the venture capital fundHealthCap.
^Raju, T N (1999), "The Nobel chronicles. 1982: Sune Karl Bergström (b 1916); Bengt Ingemar Samuelsson (b 1934); John Robert Vane (b 1927)",Lancet, vol. 354, no. 9193 (published 27 November 1999), p. 1914,doi:10.1016/s0140-6736(05)76884-7,PMID10584758,S2CID54236400
Bengt I. Samuelsson on Nobelprize.org including the Nobel LectureFrom Studies of Biochemical Mechanisms to Novel Biological Mediators: Prostaglandin Endoperoxides, Thromboxanes and Leukotrienes