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| Trade names | Vanceril, others |
| Other names | Beclometasone dipropionate; beclomethasone dipropionate, beclomethasone (USANUS) |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a681047 |
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| Routes of administration | Inhalation,nasal,topical |
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| ECHA InfoCard | 100.024.442 |
| Chemical and physical data | |
| Formula | C22H29ClO5 |
| Molar mass | 408.92 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 117 to 120 °C (243 to 248 °F) (dec.) |
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Beclometasone orbeclomethasone, sold under the brand nameVanceril among others, is asteroid medication.[5] It is available as aninhaler, cream, pills, andnasal spray.[6] The inhaled form is used in the long-term management ofasthma.[5] The cream may be used fordermatitis andpsoriasis.[7] The pills have been used to treatulcerative colitis.[8] The nasal spray is used to treatallergic rhinitis andnasal polyps.[9]
Common side effects with the inhaled form includerespiratory infections, headaches, and throat inflammation.[5] Serious side effects include an increased risk of infection,cataracts,Cushing's syndrome, andsevere allergic reactions.[5] Long-term use of the pill form may causeadrenal insufficiency.[8] The pills may also cause mood or personality changes.[8] The inhaled form is generally regarded as safe inpregnancy.[10] Beclometasone is aglucocorticoid.[5]
Beclomethasone, as beclomethasone dipropionate, was first patented in 1962 and used medically in 1972.[11] It was approved for medical use in the United States in 1976.[5] It is a therapeutic alternative on theWorld Health Organization's List of Essential Medicines.[12] In 2023, it was the 351st most commonly prescribed medication in the United States, with more than 51,000 prescriptions.[13]
Beclometasone isindicated for maintenance treatment of asthma as prophylactic therapy;[2] for the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis;[3] and the relief of the symptoms of seasonal or perennial allergic and nonallergic (vasomotor) rhinitis.[4]
Common side effects with the inhaled form includerespiratory infections, headaches, and throat inflammation.[5] Serious side effects include an increased risk of infection,cataracts,Cushing's syndrome, andsevere allergic reactions.[5] Long-term use of the pill form may causeadrenal insufficiency.[8] The pills may also cause mood or personality changes.[8] The inhaled form is generally regarded as safe inpregnancy.[10]
Occasionally, it may cause acough upon inhalation. Deposition on thetongue andthroat may promote oralcandidiasis, which appears as a white coating, possibly with irritation.[14][15][16]
Nasal corticosteroids may be associated withcentral serous retinopathy.[17]
Beclometasone is aglucocorticoid.[5] Glucocorticoids are corticosteroids that bind to theglucocorticoid receptor[18] that is present in almost everyvertebrate animal cell. The activated glucocorticoid receptor-glucocorticoid complex up-regulates the expression of anti-inflammatory proteins in thenucleus (a process known astransactivation) and represses the expression of proinflammatory proteins in thecytosol by preventing thetranslocation of othertranscription factors from the cytosol into the nucleus (transrepression).[19]
Beclometasone dipropionate is theinternational nonproprietary name modified and beclomethasone dipropionate is theUnited States Adopted Name and formerBritish Approved Name. It is aprodrug of the free form, beclometasone (INN). The prodrug beclometasone is marketed in Norway and Russia.[20][21][22][23][24]
Clenil, Qvar, Cortis are brand names for the inhalers; Beconase, Alanase, Vancenase, Qnasl for the nasal spray or aerosol.
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