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BRL-44408

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From Wikipedia, the free encyclopedia

Chemical compound (drug)

Pharmaceutical compound

BRL-44408
Clinical data

ATC code	None
Identifiers
IUPAC name 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole
CAS Number	118343-19-4^Y
PubChemCID	121850
IUPHAR/BPS	525
ChemSpider	108707^N
UNII	ZET7B198W2
ChEMBL	ChEMBL216097^N
CompTox Dashboard(EPA)	DTXSID30922665
Chemical and physical data
Formula	C₁₃H₁₇N₃
Molar mass	215.300 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N2CCN=C2CN(C1C)Cc3c1cccc3
InChI InChI=1S/C13H17N3/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13/h2-5,10H,6-9H2,1H3,(H,14,15)^N Key:SGOFAUSEYBZKDQ-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

BRL-44408 is a drug used in scientific research which acts as a selectiveantagonist for theα_2A-adrenergic receptor.^[1] It has been suggested as having potential therapeutic application in the treatment ofextrapyramidal side effects produced by someantipsychotic medications.^[2]

References

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^Alberts P (January 1993). "Subtype classification of presynaptic alpha 2-adrenoceptors".General Pharmacology.24 (1):1–8.doi:10.1016/0306-3623(93)90003-g.PMID 8387042.
^Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). "Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders".Neuroscience Letters.454 (2):143–7.doi:10.1016/j.neulet.2009.03.001.PMID 19429072.S2CID 38109591.