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BP-897

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
BP-897
Clinical data
ATC code
  • none
Identifiers
  • N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.150.041Edit this at Wikidata
Chemical and physical data
FormulaC26H31N3O2
Molar mass417.553 g·mol−1
3D model (JSmol)
  • COc1ccccc1N3CCN(CC3)CCCCNC(=O)c4ccc2ccccc2c4
  • InChI=1S/C26H31N3O2/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30) ☒N
  • Key:MNHDKMDLOJSCGN-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

BP-897 is a drug used in scientific research which acts as a potent selectivedopamineD3receptorpartial agonist with anin vitrointrinsic activity of ~0.6 and ~70x greater affinity for D3 over D2 receptors and is suspected to have partial agonist or antagonist activityin vivo.[1] It has mainly been used in the study of treatments forcocaine addiction.[2][3][4][5][6][7][8] A study comparing BP-897 with the potent, antagonistic, and highly D3 selectiveSB-277,011-A found, "SB 277011-A (1–10 mg/kg) was able to block cue-induced reinstatement of nicotine-seeking, indicating that DRD3 selective antagonism may be an effective approach to prevent relapse for nicotine. In contrast, BP 897 did not block the cue-induced reinstatement of nicotine-seeking or nicotine-taking under the FR5 schedule."[9]

References

[edit]
  1. ^Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, et al. (July 1999). "Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist".Nature.400 (6742):371–375.doi:10.1038/22560.PMID 10432116.S2CID 4351316.
  2. ^Beardsley PM, Sokoloff P, Balster RL, Schwartz JC (February 2001)."The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered".Behavioural Pharmacology.12 (1):1–11.doi:10.1097/00008877-200102000-00001.PMID 11270507.S2CID 25443354.
  3. ^Garcia-Ladona FJ, Cox BF (2003)."BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction".CNS Drug Reviews.9 (2):141–158.doi:10.1111/j.1527-3458.2003.tb00246.x.PMC 6741652.PMID 12847556.
  4. ^Duarte C, Lefebvre C, Chaperon F, Hamon M, Thiébot MH (November 2003)."Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats".Neuropsychopharmacology.28 (11):1903–1915.doi:10.1038/sj.npp.1300276.PMID 12915863.
  5. ^Hsu A, Togasaki DM, Bezard E, Sokoloff P, Langston JW, Di Monte DA, Quik M (November 2004). "Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys".The Journal of Pharmacology and Experimental Therapeutics.311 (2):770–777.doi:10.1124/jpet.104.071142.PMID 15226382.S2CID 15481124.
  6. ^Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, et al. (July 2005)."Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors".Synapse.57 (1):17–28.doi:10.1002/syn.20152.PMC 3726034.PMID 15858839.
  7. ^Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, et al. (March 2008)."The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats".Psychopharmacology.196 (4):533–542.doi:10.1007/s00213-007-0986-6.PMC 3713235.PMID 17985117.
  8. ^Hocke C, Prante O, Salama I, Hübner H, Löber S, Kuwert T, Gmeiner P (May 2008). "18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor".ChemMedChem.3 (5):788–793.doi:10.1002/cmdc.200700327.PMID 18306190.S2CID 23143152.
  9. ^Khaled MA, Farid Araki K, Li B, Coen KM, Marinelli PW, Varga J, et al. (March 2010)."The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking".The International Journal of Neuropsychopharmacology.13 (2):181–190.doi:10.1017/S1461145709991064.PMID 19995481.
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
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