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Azosemide

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Azosemide
Clinical data


AHFS/Drugs.com	International Drug Names
ATC code	none
Identifiers
IUPAC name 2-chloro-5-(2H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
CAS Number	27589-33-9^N
PubChemCID	2273
DrugBank	DB08961^N
ChemSpider	2186^Y
UNII	MR40VT1L8Z
KEGG	D01323^Y
ChEBI	CHEBI:31248^Y
ChEMBL	ChEMBL1097235^Y
CompTox Dashboard(EPA)	DTXSID7046910
ECHA InfoCard	100.044.121
Chemical and physical data
Formula	C₁₂H₁₁ClN₆O₂S₂
Molar mass	370.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=S(=O)(N)c2c(Cl)cc(c(c1n[nH]nn1)c2)NCc3sccc3
InChI InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)^Y Key:HMEDEBAJARCKCT-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Azosemide is a high-ceilingloop diuretic agent that was brought to market in 1981 byBoehringer Mannheim.^[1]^[2] As of 2015 it was available as a generic in some Asian countries.^[3]

Azosemide has been found as an adulterant inketamine.^[4]

References

[edit]

^Sittig M (1988).Pharmaceutical Manufacturing Encyclopedia(PDF). Vol. 1. Noyes Publications. p. 122.ISBN 978-0-8155-1144-1. Archived fromthe original(PDF) on 2007-10-23.
^Bormann D (January 1980). "Diuretics". In Hess HJ (ed.).Annual Reports in Medicinal Chemistry. Vol. 15. Academic Press. pp. 100–105 (101).ISBN 978-0-08-058359-4.
^"International listings for azosemide".Drugs.com. Retrieved23 July 2015.
^"Drug Checking Report 2011"(PDF).Energy Control.Archived(PDF) from the original on 20 January 2022. Retrieved20 January 2022.

Diuretics (C03)

Sulfonamides
(andetacrynic acid)

CA inhibitors (atPT)	Acetazolamide
Loop (Na-K-Cl atAL)	Furosemide^# Azosemide Bumetanide Etacrynic acid Etozolin Indacrinone Muzolimine Ozolinone Piretanide Tienilic acid^‡ Torasemide
Thiazides (Na-Cl atDCT, Calcium-sparing)	Altizide Bendroflumethiazide Butizide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide
Thiazide-likes (primarilyDCT)	Chlortalidone Clofenamide Clopamide Clorexolone Fenquizone Indapamide Mefruside Meticrane Metolazone Quinethazone Xipamide

Potassium-sparing (atCD)

ESC blockers	Amiloride^# Benzamil Triamterene
Aldosterone antagonists	Spirolactones Spironolactone^# Canrenone Eplerenone Potassium canrenoate Nonsteroidal Finerenone