Protein family
Thearyl-hydrocarbon receptor repressor also known asAHRR is a humangene .[ 1]
Dioxins and dioxin-like compounds areteratogens that exert their effects through thearyl hydrocarbon receptor (AhR) in conjunction with thereceptor 's binding partner,aryl hydrocarbon receptor nuclear translocator (ARNT). Theprotein encoded by this gene repressessignal transduction by the AhR by competing with the arylhydrocarbon receptor for binding to the ARNT.[ 2] repressor is stimulated by the receptor/translocatorheterodimer , thereby regulating receptor function through anegative feedback mechanism. In addition, the encoded protein can bind tonuclear factor-kappa B .
The AhRR gene may act as a tumor suppressor.[ 3] [ 4]
Tissue distribution [ edit ] The expression of AhRR is high in testis, lung, ovary, spleen and pancreas in adults, whereas expression is low in all tissues in fetuses.[ 5]
^ Baba T, Mimura J, Gradin K, Kuroiwa A, Watanabe T, Matsuda Y, Inazawa J, Sogawa K, Fujii-Kuriyama Y (August 2001)."Structure and expression of the Ah receptor repressor gene" .J. Biol. Chem .276 (35):33101– 10.doi :10.1074/jbc.M011497200 PMID 11423533 . ^ Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME (February 2008)."Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator" .Mol. Pharmacol .73 (2):387– 98.doi :10.1124/mol.107.040204 .PMC 3263532 PMID 18000031 . ^ Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martínez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F (February 2008)."The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers" .J. Clin. Invest .118 (2):640– 50.doi :10.1172/JCI30024 .PMC 2157559 PMID 18172554 . ^ Kanno Y, Takane Y, Izawa T, Nakahama T, Inouye Y (June 2006)."The Inhibitory Effect of Aryl Hydrocarbon Receptor Repressor (AhRR) on the Growth of Human Breast Cancer MCF-7 Cells" .Biol. Pharm. Bull .29 (6):1254– 7.doi :10.1248/bpb.29.1254 PMID 16755028 . ^ Yamamoto J, Ihara K, Nakayama H, Hikino S, Satoh K, Kubo N, Iida T, Fujii Y, Hara T (January 2004). "Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells".Life Sci .74 (8):1039– 49.doi :10.1016/j.lfs.2003.07.022 .PMID 14672759 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
