Protein-coding gene in the species Homo sapiens
Beta-arrestin-2 , orβ-arrestin2 , also known asarrestin beta-2 , is an intracellularprotein that in humans is encoded by theARRB2 gene .
Members ofarrestin /beta-arrestin protein family are thought to participate in agonist-mediated desensitization ofG protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,[ 5] [ 6] [ 7] [ 8] [ 9] [ 10] [ 11] [ 12] arrestin beta 1 , was shown to inhibitbeta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, acDNA for arrestin beta 2 was isolated fromthyroid gland , and thus it may also be involved in hormone-specific desensitization ofTSH receptors . Multiplealternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[ 13]
The protein may interact with the agonistDOI in5-HT2A receptor signaling.[ 14] [ 15]
Arrestin beta 2 is crucial for the development oftolerance tomorphine and otheropioids .
Arrestin beta 2 has been shown tointeract with
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