Aristaless related homeobox is aprotein that in humans is encoded by theARXgene.[5]
This gene is ahomeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is involved in CNS and pancreas development.[5]
Mutation in the ARX gene are associated with X-linkedintellectual disability,lissencephaly, as well ashypoglycemia (in mice).[5]
{{cite journal}}: CS1 maint: DOI inactive as of October 2025 (link)This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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