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Arachidonyl-2'-chloroethylamide

From Wikipedia, the free encyclopedia
Arachidonyl-2'-chloroethylamide
Names
Preferred IUPAC name
(5Z,8Z,11Z,14Z)-N-(2-Chloroethyl)icosa-5,8,11,14-tetraenamide
Other names
Arachidonyl-2'-chloroethylamide; ACEA
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
  • InChI=1S/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15- checkY
    Key: SCJNCDSAIRBRIA-DOFZRALJSA-N checkY
  • InChI=1/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15-
    Key: SCJNCDSAIRBRIA-DOFZRALJBU
  • ClCCNC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
Properties
C22H36ClNO
Molar mass365.99 g·mol−1
Solubility in other solventssoluble in ethanol, chloroform, THF and DMSO
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N (what is checkY☒N ?)
Chemical compound

Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of theCB1 (CB1R). ACEA is considered to be a selectivecannabinoid agonist as it binds primarily to the CB1R and has low affinity to theCB2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R).[1]

References

[edit]
  1. ^Hillard, CJ; Manna, S; Greenberg, MJ; Dicamelli, R; Ross, RA; Stevenson, LA; Murphy, V; Pertwee, RG; Campbell, WB (1999). "Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)".The Journal of Pharmacology and Experimental Therapeutics.289 (3):1427–33.doi:10.1016/S0022-3565(24)38289-8.PMID 10336536.
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Retrieved from "https://en.wikipedia.org/w/index.php?title=Arachidonyl-2%27-chloroethylamide&oldid=1318136303"
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