Anaquaretic is a novel class of drug that is used to promote aquaresis, the excretion of water withoutelectrolyte loss.[1] Strictly speaking, aquaretics are notdiuretics but are sometimes classified as such.
Aquaresis is preferable todiuresis in the treatment ofhyponatremia.[citation needed]
Aquaretics increase urine output without increasingsodium andchloride excretion, thus causing an increase in urine whilst retainingelectrolytes.[2]
A number of herbal medicines are classified as aquaretics, for examplecommon horsetail orcommon nettle leaves.[3]
Synthetic aquaretics arevasopressin receptor antagonists and includeconivaptan,tolvaptan,demeclocycline, andmozavaptan (OPC-31260), as well aslithium. Conivaptan hydrochloride and tolvaptan have been approved by the FDA for treatingsyndrome of inappropriate antidiuretic hormone.[4][5] Mozavaptan is approved in Japan.[citation needed]
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