Aquaporin 3 (AQP-3) is the protein product of the humanAQP3 gene.[5] It is found in the basolateral cell membrane of principalcollecting duct cells and provides a pathway for water to exit these cells.[6] Aquaporin-3 is also permeable toglycerol,ammonia,urea, andhydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers.[7] In the kidney, aquaporin-3 is unresponsive to the antidiuretic hormonevasopressin, unlikeaquaporin-2.[8] This protein is also a determinant for the GIL blood group system.[9]
Recent studies indicate that aquaporin 3 is overexpressed in many types of malignancies such asmelanoma[7] andprimary effusion lymphomas[12] as well as cancers of the lung, colon, stomach, esophagus, mouth, liver, and pancreatic duct.[5][12] Based on these as well ascell culture studies, it is suggested that this overexpression contributes to the growth and spread of at least some of these cancers and therefore may be a therapeutic target for the treatment of these cancers.[5][7][12]
^Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct".Annu. Rev. Physiol.60:199–220.doi:10.1146/annurev.physiol.60.1.199.PMID9558461.
Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte".Mol. Biochem. Parasitol.167 (1):48–53.doi:10.1016/j.molbiopara.2009.04.006.PMID19393693.
Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations".Transfusion.48 (6):1164–8.doi:10.1111/j.1537-2995.2008.01683.x.PMID18435676.S2CID5795042.
Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture".J. Soc. Gynecol. Investig.13 (3):181–5.doi:10.1016/j.jsgi.2006.02.002.PMID16638588.S2CID30438043.
Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells".Respiratory Physiology & Neurobiology.161 (2):111–8.doi:10.1016/j.resp.2007.12.007.PMID18280225.S2CID25006640.
Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine".Biochem. Biophys. Res. Commun.373 (4):613–7.doi:10.1016/j.bbrc.2008.06.086.PMID18601899.
Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes".Biochem. Biophys. Res. Commun.387 (3):564–8.doi:10.1016/j.bbrc.2009.07.077.PMID19619514.
Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin".J. Cell. Biochem.102 (4):1051–8.doi:10.1002/jcb.21350.PMID17471492.S2CID7045806.
Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation".J. Cell. Physiol.217 (2):338–49.doi:10.1002/jcp.21506.PMID18543247.S2CID900588.
Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line".J. Membr. Biol.208 (1):55–64.doi:10.1007/s00232-005-0819-7.PMID16596446.S2CID11479553.
Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues".Hum. Pathol.38 (1):171–8.doi:10.1016/j.humpath.2006.07.015.PMID17056099.
