Dementia is asyndrome associated with manyneurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to performeveryday activities.[10] This typically involves problems withmemory,thinking,behavior, andmotor control.[11] Aside frommemory impairment and adisruption in thought patterns, the most common symptoms of dementia include emotional problems, difficulties withlanguage, and decreasedmotivation.[2] The symptoms may be described as occurring in acontinuum over several stages.[12][a] Dementia ultimately has a significant effect on the individual, theircaregivers, and their social relationships in general.[2] A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greatercognitive decline than might be caused by the normalaging process.[14]
Diagnosis of dementia is usually based onhistory of the illness andcognitive testing withimaging.Blood tests may be taken to rule out other possible causes that may be reversible, such as hypothyroidism (an underactive thyroid), and to determine the dementia subtype. One commonly used cognitive test is themini–mental state examination. Although the greatest risk factor for developing dementia is aging, dementia is not a normal part of the aging process; many people aged 90 and above show no signs of dementia.[19] Several risk factors for dementia, such as smoking andobesity, are preventable by lifestyle changes.Screening the general older population for the disorder is not seen to affect the outcome.[20]
Dementia is currently the seventh leading cause of death worldwide and has 10 million new cases reported every year (approximately one every three seconds).[2] There is no knowncure for dementia.Acetylcholinesterase inhibitors such asdonepezil are often used and may be beneficial in mild to moderate disorder, but the overall benefit may be minor. There are many measures that can improve the quality of life of a person with dementia and their caregivers.Cognitive and behavioral interventions may be appropriate for treating the associated symptoms of depression.[21]
The behavioral symptoms can includeagitation, restlessness, inappropriate behavior, sexual disinhibition, and verbal or physical aggression.[24] These symptoms may result from impairments incognitive inhibition.[25]
The psychological symptoms can include depression,hallucinations (most often visual),[26] delusions, apathy, and anxiety.[24][27] The most commonly affected areas of brain function includememory,language,attention,problem solving, andvisuospatial function affecting perception and orientation. The symptoms progress at a continuous rate over several stages, and they vary across the dementia subtypes.[28][12] Most types of dementia are slowly progressive with some deterioration of the brain well established before signs of the disorder become apparent. There are oftenother conditions present, such ashigh blood pressure ordiabetes, and there can sometimes be as many as four of these comorbidities.[29]
Signs of dementia include getting lost in a familiar neighborhood, using unusual words to refer to familiar objects, forgetting the name of a close family member or friend, forgetting old memories, and being unable to complete tasks independently.[30] People with developing dementia often fall behind on bill payments; specifically mortgage and credit cards, and a crashingcredit score can be an early indicator of the disease.[31][32]
People with dementia are more likely to have problems with incontinence than those of a comparable age without dementia; they are three times more likely to haveurinary incontinence and four times more likely to havefecal incontinence.[33][34]
The course of dementia is often described in four stages (pre-dementia, early, middle, and late) that show a pattern of progressive cognitive and functional impairment.
More detailed descriptions can be arrived at by the use of numeric scales. These scales include:
Using the GDS, which more accurately identifies each stage of the disease progression, a more detailed course is described in seven stages – two of which are broken down further into five and six degrees. Stage 7(f) is the final stage.[42][43]
Sensory dysfunction is claimed for the pre-clinical stage, which may precede the first clinical signs of dementia by up to ten years.[12] Most notably thesense of smell is lost,[12][45] associated with depression and a loss of appetite leading to poor nutrition.[46] It is suggested thatthis dysfunction may come about because theolfactory epithelium is exposed to the environment, and the lack ofblood–brain barrier protection allows toxic elements to enter and cause damage to thechemosensory networks.[12]
Pre-dementia states considered as prodromal aremild cognitive impairment (MCI) andmild behavioral impairment (MBI).[47][48][49] Signs and symptoms at the prodromal stage may be subtle, and the early signs often become apparent only in hindsight.[50] Of those diagnosed with MCI, 70% later progress to dementia.[14] In mild cognitive impairment, changes in the person's brain have been happening for a long time, but the symptoms are just beginning to appear. These problems, however, are not severe enough to affect daily function. If and when they do, the diagnosis becomes dementia. The person may have some memory problems and trouble finding words, but they can solve everyday problems and competently handle their life affairs.[51] During this stage, it is ideal to ensure that advance care planning has occurred to protect the person's wishes. Advance directives exist that are specific to sufferers of dementia;[52] these can be particularly helpful in addressing the decisions related to feeding which come with the progression of the illness. Mild cognitive impairment has been relisted in bothDSM-5 andICD-11 as "mild neurocognitive disorders", i.e. milder forms of the major neurocognitive disorder (dementia) subtypes.[53]
Kynurenine is a metabolite oftryptophan that regulates microbiome signaling, immune cell response, and neuronal excitation. A disruption in thekynurenine pathway may be associated with the neuropsychiatric symptoms and cognitive prognosis in mild dementia.[54][55]
In the early stage of dementia, symptoms become noticeable to other people. In addition, the symptoms begin to interfere with daily activities, and will register a score on amini–mental state examination (MMSE). MMSE scores are set at 24 to 30 for a normal cognitive rating and lower scores reflect severity of symptoms. The symptoms are dependent on the type of dementia. More complicated chores and tasks around the house or at work become more difficult. The person can usually still take care of themselves but may forget things like taking pills or doing laundry and may need prompting or reminders.[56]
The symptoms of early dementia usually include memory difficulty, but can also include someword-finding problems, and problems withexecutive functions of planning and organization.[57] Managing finances may prove difficult. Other signs might be getting lost in new places, repeating things, and personality changes.[58]
As dementia progresses, initial symptoms generally worsen. The rate of decline is different for each person. MMSE scores between 6 and 17 signal moderate dementia. For example, people with moderate Alzheimer's dementia lose almost all new information. People with dementia may be severely impaired in solving problems, and their social judgment is often impaired. They cannot usually function outside their own home, and generally should not be left alone. They may be able to do simple chores around the house but not much else, and begin to require assistance for personal care and hygiene beyond simple reminders.[14] Alack of insight into having the condition will become evident.[60][61]
People with late-stage dementia typically turn increasingly inward and need assistance with most or all of their personal care. People with dementia in the late stages usually need 24-hour supervision to ensure their personal safety, and meeting of basic needs. If left unsupervised, they maywander or fall; may not recognize common dangers such as a hot stove; or may not realize that they need to use the bathroom and becomeincontinent.[51] They may not want to get out of bed, or may need assistance doing so. Commonly, the person no longer recognizes familiar faces. They may have significant changes in sleeping habits or have trouble sleeping at all.[14]
Changes in eating frequently occur. Cognitive awareness is needed for eating and swallowing and progressive cognitive decline results in eating andswallowing difficulties. This can cause food to be refused, or choked on, and help with feeding will often be required.[62] For ease of feeding, food may be liquidized into a thick purée. They may also struggle to walk, particularly among those withAlzheimer's disease.[63][64][65] In some cases,terminal lucidity, a form ofparadoxical lucidity, occurs immediately before death; in this phenomenon, there is an unexpected recovery of mental clarity.[66]
Alzheimer's disease accounts for 60–70% of cases of dementia worldwide. The most common symptoms of Alzheimer's disease areshort-term memory loss andword-finding difficulties. Trouble withvisuospatial functioning (getting lost often), reasoning, judgment andinsight fail. Insight refers to whether or not the person realizes they have memory problems.
The part of the brain most affected by Alzheimer's is thehippocampus. Other parts that showatrophy (shrinking) include thetemporal andparietal lobes. Although this pattern of brain shrinkage suggests Alzheimer's, it is variable and a brain scan is insufficient for a diagnosis.
Little is known about the events that occur during and that actually cause Alzheimer's disease. This is due to the fact that, historically, brain tissue from patients with the disease could only be studied after the person's death. Brain scans can now help diagnose and distinguish between different kinds of dementia and show severity. These include magnetic resonance imaging (MRI), computerized tomography (CT), and positron emission tomography (PET). However, it is known that one of the first aspects of Alzheimer's disease is overproduction ofamyloid. Extracellular senile plaques (SPs), consisting of beta-amyloid (Aβ) peptides, and intracellularneurofibrillary tangles (NFTs) that are formed by hyperphosphorylated tau proteins, are two well-established pathological hallmarks of AD.[73] Amyloid causesinflammation around thesenile plaques of the brain, and too much buildup of this inflammation leads to changes in the brain that cannot be controlled, leading to the symptoms of Alzheimer's.[74]
Several articles have been published on a possible relationship (as an either primary cause or exacerbation of Alzheimer's disease) between generalanesthesia and Alzheimer's in specificallythe elderly.[75]
Vascular dementia accounts for at least 20% of dementia cases, making it the second most common type.[76] It is caused by disease or injury affecting theblood supply to the brain, typically involving a series ofmini-strokes. The symptoms of this dementia depend on where in the brain the strokes occurred and whether the blood vessels affected were large or small.[14] Repeated injury can cause progressive dementia over time, while a single injury located in an area critical for cognition such as the hippocampus, or thalamus, can lead to sudden cognitive decline.[76] Elements of vascular dementia may be present in all other forms of dementia.[77]
The prodromal symptoms of dementia with Lewy bodies (DLB) includemild cognitive impairment, anddelirium onset.[79]The symptoms of DLB are more frequent, more severe, and earlier presenting than in the other dementia subtypes.[80]Dementia with Lewy bodies has the primary symptoms of fluctuating cognition, alertness or attention;REM sleep behavior disorder (RBD); one or more of the main features ofparkinsonism, not due to medication or stroke; and repeated visual hallucinations.[81] The visual hallucinations in DLB are generally vivid hallucinations of people or animals and they often occur when someone is about to fall asleep or wake up. Other prominent symptoms include problems with planning (executive function) and difficulty with visual-spatial function,[14] and disruption inautonomic bodily functions.[82] Abnormal sleep behaviors may begin before cognitive decline is observed and are a core feature of DLB.[81] RBD is diagnosed either by sleep study recording or, when sleep studies cannot be performed, by medical history and validated questionnaires.[81]
Frontotemporal dementias (FTDs) are characterized by drastic personality changes and language difficulties. In all FTDs, the person has a relatively early social withdrawal and early lack of insight. Memory problems are not a main feature.[14][84] There are six main types of FTD. The first has major symptoms in personality and behavior. This is calledbehavioral variant FTD (bv-FTD) and is the most common. The hallmark feature of bv-FTD isimpulsive behavior, and this can be detected in pre-dementia states.[49] In bv-FTD, the person shows a change in personal hygiene, becomes rigid in their thinking, and rarely acknowledges problems; they are socially withdrawn, and often have a drastic increase in appetite. They may become socially inappropriate. For example, they may make inappropriate sexual comments, or may begin using pornography openly. One of the most common signs isapathy, or not caring about anything. Apathy, however, is a common symptom in many dementias.[14]
Two types of FTD featureaphasia (language problems) as the main symptom. One type is called semantic variant primary progressive aphasia (SV-PPA). The main feature of this is the loss of the meaning of words. It may begin with difficulty naming things. The person eventually may lose the meaning of objects as well. For example, a drawing of a bird, dog, and an airplane in someone with FTD may all appear almost the same.[14] In a classic test for this, a patient is shown a picture of a pyramid and below it a picture of both a palm tree and a pine tree. The person is asked to say which one goes best with the pyramid. In SV-PPA the person cannot answer that question. The other type is called non-fluent agrammatic variant primary progressive aphasia (NFA-PPA). This is mainly a problem with producing speech. They have trouble finding the right words, but mostly they have a difficulty coordinating the muscles they need to speak. Eventually, someone with NFA-PPA only uses one-syllable words or may become totally mute.
Huntington's disease is aneurodegenerative disease caused by mutations in a single geneHTT, that encodes forhuntingtin protein. Symptoms include cognitive impairment and this usually declines further into dementia.[87]
The first main symptoms of Huntington's disease often include:
difficulty concentrating
memory lapses
depression - this can include low mood, lack of interest in things, or just abnormal feelings of hopelessness
stumbling and clumsiness that is out of the ordinary
mood swings, such as irritability or aggressive behavior to insignificant things[88]
HIV-associated dementia results as a late stage fromHIV infection, and mostly affects younger people.[89] The essential features of HIV-associated dementia are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change.[89] Cognitive impairment is characterised by mental slowness, trouble withmemory and poorconcentration. Motor symptoms include a loss of fine motor control leading to clumsiness, poor balance and tremors. Behavioral changes may includeapathy,lethargy and diminished emotional responses and spontaneity.Histopathologically, it is identified by the infiltration ofmonocytes andmacrophages into thecentral nervous system (CNS),gliosis, pallor ofmyelin sheaths, abnormalities ofdendritic processes andneuronal loss.[90]
Creutzfeldt–Jakob disease is a rapidly progressiveprion disease that typically causes dementia that worsens over weeks to months.Prions are disease-causing pathogens created from abnormal proteins.[91]
Alcohol-related dementia, also called alcohol-related brain damage, occurs as a result of excessive use ofalcohol particularly as a substance abuse disorder. Different factors can be involved in this development includingthiamine deficiency and age vulnerability.[92][93] A degree of brain damage is seen in more than 70% of those withalcohol use disorder. Brain regions affected are similar to those that are affected by aging, and also by Alzheimer's disease. Regions showing loss of volume include the frontal, temporal, and parietal lobes, as well as the cerebellum, thalamus, and hippocampus.[93] This loss can be more notable, with greater cognitive impairments seen in those aged 65 years and older.[93]
More than one type of dementia, known as mixed dementia, may exist together in about 10% of dementia cases.[2] The most common type of mixed dementia is Alzheimer's disease and vascular dementia.[94] This particular type of mixed dementia's main onsets are a mixture of old age, high blood pressure, and damage to blood vessels in the brain.[16]
Diagnosis of mixed dementia can be difficult, as often only one type will predominate. This makes the treatment of people with mixed dementia uncommon, with many people missing out on potentially helpful treatments. Mixed dementia can mean that symptoms onset earlier, and worsen more quickly since more parts of the brain will be affected.[16]
Celiac disease does not seem to raise the risk of dementia in general but it may increase the risk of vascular dementia.[97] Both celiac disease or non-celiac gluten sensitivity might raise the risk of cognitive impairment which can be one of the early signs of subsequent dementia.[98] A strictgluten-free diet started early may protect against dementia associated withgluten-related disorders.[97][98]
Cases of easily reversible dementia includehypothyroidism,vitamin B12 deficiency,Lyme disease, andneurosyphilis. For Lyme disease and neurosyphilis, testing should be done if risk factors are present. Because risk factors are often difficult to determine, testing for neurosyphilis and Lyme disease, as well as other mentioned factors, may be undertaken as a matter of course where dementia is suspected.[14]: 31–32
Persistent loneliness may significantly increase the risk of dementia.[102][103] Loneliness is associated with a 31% higher likelihood of developing any form of dementia, and can also raise the risk of cognitive impairment by 15%.[103]
Symptoms are similar across dementia types and it is difficult to diagnose by symptoms alone. Diagnosis may be aided bybrain scanning techniques. In many cases, the diagnosis requires abrain biopsy to become final, but this is rarely recommended (though it can be performed atautopsy). In those who are getting older, general screening forcognitive impairment using cognitive testing or early diagnosis of dementia has not been shown to improve outcomes.[20][104] However, screening exams are useful in 65+ persons with memory complaints.[14]
Normally, symptoms must be present for at least six months to support a diagnosis.[105] Cognitive dysfunction of shorter duration is calleddelirium. Delirium can be easily confused with dementia due to similar symptoms. Delirium is characterized by a sudden onset, fluctuating course, a short duration (often lasting from hours to weeks), and is primarily related to a somatic (or medical) disturbance. In comparison, dementia has typically a long, slow onset (except in the cases of a stroke or trauma), slow decline of mental functioning, as well as a longer trajectory (from months to years).[106]
Somemental illnesses, including depression andpsychosis, may produce symptoms that must bedifferentiated from both delirium and dementia.[107] These are differently diagnosed aspseudodementias, and any dementia evaluation needs to include a depression screening such as the Neuropsychiatric Inventory or theGeriatric Depression Scale.[108][14] Physicians used to think that people with memory complaints had depression and not dementia (because they thought that those with dementia are generally unaware of their memory problems). However, researchers have realized that many older people with memory complaints in fact have mild cognitive impairment the earliest stage of dementia. Depression should always remain high on the list of possibilities, however, for an elderly person with memory trouble. Changes in thinking, hearing and vision are associated with normal ageing and can cause problems when diagnosing dementia due to the similarities.[109] Given the challenging nature of predicting the onset of dementia and making a dementia diagnosis clinical decision making aids underpinned by machine learning and artificial intelligence have the potential to enhance clinical practice.[110]
Various briefcognitive tests (5–15 minutes) have reasonable reliability to screen for dementia, but may be affected by factors such as age, education and ethnicity.[113] Age and education have a significant influence on the diagnosis of dementia. For example, Individuals with lower education are more likely to be diagnosed with dementia than their educated counterparts.[114] While many tests have been studied,[115][116][117] presently themini mental state examination (MMSE) is the best studied and most commonly used. The MMSE is a useful tool for helping to diagnose dementia if the results are interpreted along with an assessment of a person's personality, their ability to perform activities of daily living, and their behaviour.[4] Other cognitive tests include theabbreviated mental test score (AMTS), the, "modified mini–mental state examination" (3MS),[118] theCognitive Abilities Screening Instrument (CASI),[119] theTrail-making test,[120] and theclock drawing test.[41] The MoCA (Montreal Cognitive Assessment) is a reliable screening test and is available online for free in 35 different languages.[14] The MoCA has also been shown somewhat better at detecting mild cognitive impairment than the MMSE.[121][48] People withhearing loss, which commonly occurs alongside dementia, score worse in the MoCA test, which could lead to a false diagnosis of dementia. Researchers have developed an adapted version of the MoCA test, which is accurate and reliable and avoids the need for people to listen and respond to questions.[122][123] The AD-8 – a screening questionnaire used to assess changes in function related to cognitive decline – is potentially useful, but is not diagnostic, is variable, and has risk of bias.[124] Anintegrated cognitive assessment (CognICA) is a five-minute test that is highly sensitive to the early stages of dementia, and uses an application deliverable to aniPad.[125][126] Previously in use in the UK, in 2021 CognICA was givenFDA approval for its commercial use as amedical device.[126]
Another approach to screening for dementia is to ask an informant (relative or other supporter) to fill out a questionnaire about the person's everyday cognitive functioning. Informant questionnaires provide complementary information to brief cognitive tests. Probably the best known questionnaire of this sort is theInformant Questionnaire on Cognitive Decline in the Elderly (IQCODE).[127] Evidence is insufficient to determine how accurate the IQCODE is for diagnosing or predicting dementia.[128] The Alzheimer's Disease Caregiver Questionnaire is another tool. It is about 90% accurate for Alzheimer's when by a caregiver.[14] TheGeneral Practitioner Assessment Of Cognition combines both a patient assessment and an informant interview. It was specifically designed for use in the primary care setting.
Clinical neuropsychologists provide diagnostic consultation following administration of a full battery of cognitive testing, often lasting several hours, to determine functional patterns of decline associated with varying types of dementia. Tests of memory, executive function, processing speed, attention and language skills are relevant, as well as tests of emotional and psychological adjustment. These tests assist with ruling out other etiologies and determining relative cognitive decline over time or from estimates of prior cognitive abilities.[129]
ACT scan orMRI scan is commonly performed to possibly find eithernormal pressure hydrocephalus, a potentially reversible cause of dementia, or connected tumor. The scans can also yield information relevant to other types of dementia, such as infarction (stroke) that would point at a vascular type of dementia. These tests do not pick up diffuse metabolic changes associated with dementia in a person who shows no gross neurological problems (such as paralysis or weakness) on a neurological exam.[131]
Thefunctional neuroimaging modalities ofSPECT andPET are more useful in assessing long-standing cognitive dysfunction, since they have shown similar ability to diagnose dementia as a clinical exam and cognitive testing.[132] The ability of SPECT to differentiate vascular dementia from Alzheimer's disease, appears superior to differentiation by clinical exam.[133]
The value ofPiB-PET imaging usingPittsburgh compound B (PiB) as aradiotracer has been established in predictive diagnosis, particularly Alzheimer's disease.[134]
Risk factors for dementia includehigh blood pressure, high levels ofLDL cholesterol,vision loss,hearing loss,smoking,obesity,depression,inactivity,diabetes, lower levels of education and low social contact. Over-indulgence in alcohol, lack of sleep,anemia, traumatic brain injury, and air pollution can also increase the chance of developing dementia.[7][135][136][137] Many of these risk factors, including the lower level of education, smoking, physical inactivity and diabetes, are modifiable.[138] Several of the group are known asvascular risk factors that may be possible to be reduced or eliminated.[139] Managing these risk factors can reduce the risk of dementia in individuals in their late midlife or older age. A reduction in a number of these risk factors can give a positive outcome.[140] The decreased risk achieved by adopting a healthy lifestyle is seen even in those with a high genetic risk.[141]
In addition to the above risk factors, other psychological features, including certain personality traits (highneuroticism, and lowconscientiousness), lowpurpose in life, and highloneliness, are risk factors for Alzheimer's disease and related dementias.[142][143][144] For example, based on theEnglish Longitudinal Study of Ageing (ELSA), research found that loneliness in older people can increase the risk of dementia by one-third. Not having a partner (being single, divorced, or widowed) can double the risk of dementia. However, having two or three closer relationships might reduce the risk by three-fifths.[145][146]
The two most modifiable risk factors for dementia arephysical inactivity and lack of cognitive stimulation.[147] Physical activity, in particularaerobic exercise, is associated with a reduction in age-related brain tissue loss, and neurotoxic factors thereby preserving brain volume and neuronal integrity. Cognitive activity strengthensneural plasticity and together they help to supportcognitive reserve. The neglect of these risk factors diminishes this reserve.[147]
Sensory impairments of vision and hearing are modifiable risk factors for dementia.[148][149][150] These impairments may precede the cognitive symptoms of Alzheimer's disease for example, by many years.[151] Hearing loss may lead tosocial isolation which negatively affects cognition.[152] Social isolation is also identified as a modifiable risk factor.[151] Age-related hearing loss in midlife is linked to cognitive impairment in late life, and is seen as a risk factor for the development of Alzheimer's disease and dementia. Such hearing loss may be caused by acentral auditory processing disorder that makes the understanding of speech against background noise difficult. Age-related hearing loss is characterised by slowed central processing of auditory information.[151][153] Worldwide, mid-life hearing loss may account for around 9% of dementia cases.[154]
Frailty may increase the risk of cognitive decline, and dementia, and the inverse also holds of cognitive impairment increasing the risk of frailty. Prevention of frailty may help to prevent cognitive decline.[151]
There are no medications that can prevent cognitive decline and dementia.[155] However blood pressure lowering medications might decrease the risk of dementia or cognitive problems by around 0.5%.[156]
Economic disadvantage has been shown to have a strong link to higher dementia prevalence,[157] which cannot yet be fully explained by other risk factors.
A modelling study suggested that population-level interventions that target risk factors for dementia (such as high blood pressure, smoking and obesity) in England could save money and give people extra years in good health. For example, reduced salt in food could give 39,433 quality-adjusted life-years and save £2.4 billion.[158][159]
Limited evidence links poor oral health to cognitive decline. However, failure to perform tooth brushing and gingival inflammation can be used as dementia risk predictors.[160]
The link between Alzheimer's andgum disease isoral bacteria.[161] In the oral cavity, bacterial species includeP. gingivalis,F. nucleatum,P. intermedia, andT. forsythia. Six oral treponemaspirochetes have been examined in the brains of Alzheimer's patients.[162] Spirochetes are neurotropic in nature, meaning they act to destroy nerve tissue and create inflammation. Inflammatory pathogens are an indicator of Alzheimer's disease and bacteria related to gum disease have been found in the brains of patients with Alzheimer's disease.[162] The bacteria invade nerve tissue in the brain, increasing the permeability of theblood–brain barrier and promoting the onset of Alzheimer's. Individuals with a plethora of tooth plaque risk cognitive decline.[163] Poor oral hygiene can have an adverse effect on speech and nutrition, causing general and cognitive health decline.
Herpes simplex virus (HSV) has been found in more than 70% of those aged over 50. HSV persists in the peripheral nervous system and can be triggered by stress, illness or fatigue.[162] High proportions of viral-associated proteins inamyloid plaques orneurofibrillary tangles (NFTs) confirm the involvement of HSV-1 in Alzheimer's disease pathology. NFTs are known as the primary marker of Alzheimer's disease. HSV-1 produces the main components of NFTs.[164]
Diet is seen to be a modifiable risk factor for the development of dementia. Thiamine deficiency is identified to increase the risk of Alzheimer's disease in adults.[165] The role of thiamine in brain physiology is unique and essential for the normal cognitive function of older people.[166] Many dietary choices of the elderly population, including the higher intake of gluten-free products, compromise the intake of thiamine as these products are not fortified with thiamine.[167]
TheMediterranean andDASH diets are both associated with less cognitive decline. A different approach has been to incorporate elements of both of these diets into one known as theMIND diet.[168] These diets are generally low in saturated fats while providing a good source of carbohydrates, mainly those that help stabilize blood sugar and insulin levels.[169] Raisedblood sugar levels over a long time, can damage nerves and cause memory problems if they are not managed.[170] Nutritional factors associated with the proposed diets for reducing dementia risk includeunsaturated fatty acids,vitamin E,vitamin C,flavonoids,vitamin B, andvitamin D.[171][172] A study conducted at the University of Exeter in the United Kingdom seems to have confirmed these findings with fruits, vegetables, whole grains, and healthy fats creating an optimum diet that can help reduce the risk of dementia by roughly 25%.[173]
The MIND diet may be more protective but further studies are needed. The Mediterranean diet seems to be more protective against Alzheimer's than DASH but there are no consistent findings against dementia in general. The role ofolive oil needs further study as it may be one of the most important components in reducing the risk of cognitive decline and dementia.[168][174]
Omega-3 fatty acid supplements do not appear to benefit or harm people with mild to moderate symptoms.[175] However, there is good evidence that omega-3 incorporation into the diet is of benefit in treating depression, a common symptom,[176] and potentially modifiable risk factor for dementia.[7]
There are limited options for treating dementia, with most approaches focused on managing or reducing individual symptoms. There are no treatment options available to delay the onset of dementia.[177]Acetylcholinesterase inhibitors are often used early in the disorder course; however, benefit is generally small.[8][178] More than half of people with dementia may experience psychological or behavioral symptoms including agitation, sleep problems, aggression, and/or psychosis. Treatment for these symptoms is aimed at reducing the person's distress and keeping the person safe. Treatments other than medication appear to be better for agitation and aggression.[179] Cognitive and behavioral interventions may be appropriate. Some evidence suggests that education and support for the person with dementia, as well as caregivers and family members, improves outcomes.[180] Palliative care interventions may lead to improvements in comfort in dying, but the evidence is low.[181] Exercise programs are beneficial with respect to activities of daily living, and potentially improve dementia.[182]
The effect of therapies can be evaluated for example by assessing agitation using the Cohen-Mansfield Agitation Inventory (CMAI); by assessing mood and engagement with the Menorah Park Engagement Scale (MPES);[183] and the Observed Emotion Rating Scale (OERS)[184] or by assessing indicators for depression using the Cornell Scale for Depression in Dementia (CSDD)[185] or a simplified version thereof.[186]
Often overlooked in treating and managing dementia is the role of the caregiver and what is known about how they can support multiple interventions. Findings from a 2021 systematic review of the literature found caregivers of people with dementia in nursing homes do not have sufficient tools or clinical guidance for behavioral and psychological symptoms of dementia (BPSD) along with medication use.[187] Simple measures like talking to people about their interests can improve the quality of life forcare home residents living with dementia. A programme showed that such simple measures reduced residents' agitation and depression. They also needed fewer GP visits and hospital admissions, which also meant that the programme was cost-saving.[188][189]
Psychological therapies for dementia include some limited evidence forreminiscence therapy (namely, some positive effects in the areas of quality of life, cognition, communication and mood – the first three particularly in care home settings),[190] some benefit forcognitive reframing for caretakers,[191] unclear evidence forvalidation therapy[192] and tentative evidence formental exercises, such as cognitive stimulation programs for people with mild to moderate dementia.[193] Offering personally tailored activities may help reduce challenging behavior and may improve quality of life.[194] It is not clear if personally tailored activities have an impact onaffect or improve for the quality of life for the caregiver.[194]
Adult daycare centers as well as special care units in nursing homes often provide specialized care for dementia patients. Daycare centers offer supervision, recreation, meals, and limited health care to participants, as well as providing respite for caregivers. In addition,home care can provide one-to-one support and care in the home allowing for more individualized attention that is needed as the disorder progresses. Psychiatric nurses can make a distinctive contribution to people's mental health.[195]
Since dementia impairs normal communication due to changes in receptive and expressive language, as well as the ability to plan and problem solve, agitated behavior is often a form of communication for the person with dementia. Actively searching for a potential cause, such as pain, physical illness, or overstimulation can be helpful in reducing agitation.[196] Additionally, using an "ABC analysis of behavior" can be a useful tool for understanding behavior in people with dementia. It involves looking at the antecedents (A), behavior (B), and consequences (C) associated with an event to help define the problem and prevent further incidents that may arise if the person's needs are misunderstood.[197] The strongest evidence for non-pharmacological therapies for the management of changed behaviors in dementia is for using such approaches.[198] Low quality evidence suggests that regular (at least five sessions of)music therapy may help institutionalized residents. It may reduce depressive symptoms and improve overall behaviors. It may also supply a beneficial effect on emotional well-being and quality of life, as well as reduce anxiety.[199] In 2003, TheAlzheimer's Society established 'Singing for the Brain' (SftB) a project based on pilot studies which suggested that the activity encouraged participation and facilitated the learning of new songs. The sessions combine aspects of reminiscence therapy and music.[200] Musical and interpersonal connectedness can underscore the value of the person and improve quality of life.[201]
Some London hospitals found that using color, designs, pictures and lights helped people with dementia adjust to being at the hospital. These adjustments to the layout of the dementia wings at these hospitals helped patients by preventing confusion.[202]
Life story work as part ofreminiscence therapy, and video biographies have been found to address the needs of clients and their caregivers in various ways, offering the client the opportunity to leave a legacy and enhance their personhood and also benefitting youth who participate in such work. Such interventions can be more beneficial when undertaken at a relatively early stage of dementia. They may also be problematic in those who have difficulties in processing past experiences[201]
Animal-assisted therapy has been found to be helpful. Drawbacks may be that pets are not always welcomed in a communal space in the care setting. An animal may pose a risk to residents, or may be perceived to be dangerous. Certain animals may also be regarded as "unclean" or "dangerous" by some cultural groups.[201]
Occupational therapy also addresses psychological and psychosocial needs of patients with dementia through improving daily occupational performance and caregivers' competence.[203] When compensatory intervention strategies are added to their daily routine, the level of performance is enhanced and reduces the burden commonly placed on their caregivers.[203] Occupational therapists can also work with other disciplines to create a client centered intervention.[204] To manage cognitive disability, and coping with behavioral and psychological symptoms of dementia, combined occupational and behavioral therapies can support patients with dementia even further.[204]
There is no strong evidence to suggest thatcognitive training is beneficial for people with Parkinson's disease, dementia, or mild cognitive impairment.[205] However, a 2023 review found thatcognitive rehabilitation may be effective in helping individuals with mild to moderate dementia to manage their daily activities.[206]
No medications have been shown to prevent or cure dementia.[208] Medications may be used to treat the behavioral and cognitive symptoms, but have no effect on the underlying disease process.[14][209]
Donepezil
Acetylcholinesterase inhibitors, such asdonepezil, may be useful for Alzheimer's disease,[210] Parkinson's disease dementia, DLB, or vascular dementia.[209] The quality of the evidence is poor[211] and the benefit is small.[8] No difference has been shown between the agents in this family.[212] In a minority of people side effects include aslow heart rate andfainting.[213]Rivastigmine is recommended for treating symptoms in Parkinson's disease dementia.[71]
Medications that haveanticholinergic effects increase all-cause mortality in people with dementia, although the effect of these medications on cognitive function remains uncertain, according to a systematic review published in 2021.[214]
Before prescribing antipsychotic medication in the elderly, an assessment for an underlying cause of the behavior is needed.[215] Severe and life-threatening reactions occur in almost half of people with DLB,[82][216] and can be fatal after a single dose.[217] People with Lewy body dementias who take neuroleptics are at risk for neuroleptic malignant syndrome, a life-threatening illness.[218] Extreme caution is required in the use of antipsychotic medication in people with DLB because of their sensitivity to these agents.[81] Antipsychotic drugs are used to treat dementia only if non-drug therapies have not worked, and the person's actions threaten themselves or others.[219][220][221][222] Aggressive behavior changes are sometimes the result of other solvable problems, that could make treatment with antipsychotics unnecessary.[219] Because people with dementia can be aggressive, resistant to their treatment, and otherwise disruptive, sometimes antipsychotic drugs are considered as a therapy in response.[219] These drugs have risky adverse effects, including increasing the person's chance of stroke and death.[219] Given these adverse events and small benefit antipsychotics are avoided whenever possible.[198] Generally, stopping antipsychotics for people with dementia does not cause problems, even in those who have been on them a long time.[223]
N-methyl-D-aspartate (NMDA) receptor blockers such asmemantine may be of benefit but the evidence is less conclusive than for AChEIs.[210] Due to their differing mechanisms of action memantine and acetylcholinesterase inhibitors can be used in combination however the benefit is slight.[224][225]
An extract ofGinkgo biloba known asEGb 761 has been widely used for treating mild to moderate dementia and other neuropsychiatric disorders.[226] Its use is approved throughout Europe.[227] The World Federation of Biological Psychiatry guidelines lists EGb 761 with the same weight of evidence (level B) given to acetylcholinesterase inhibitors, and memantine. EGb 761 is the only one that showed improvement of symptoms in both AD and vascular dementia. EGb 761 is seen as being able to play an important role either on its own or as an add-on particularly when other therapies prove ineffective.[226] EGb 761 is seen to be neuroprotective; it is a free radical scavenger, improves mitochondrial function, and modulatesserotonin and dopamine levels. Many studies of its use in mild to moderate dementia have shown it to significantly improve cognitive function, activities of daily living, neuropsychiatric symptoms, and quality of life.[226][228] However, its use has not been shown to prevent the progression of dementia.[226]
No solid evidence indicates thatfolate orvitamin B12 improves outcomes in those with cognitive problems.[232]Statins have no benefit in dementia.[233] Medications for other health conditions may need to be managed differently for a person who has a dementia diagnosis. It is unclear whether blood pressure medication and dementia are linked. People may experience an increase in cardiovascular-related events if these medications are withdrawn.[234]
TheMedication Appropriateness Tool for Comorbid Health Conditions in Dementia (MATCH-D) criteria can help identify ways that a diagnosis of dementia changes medication management for other health conditions.[235] These criteria were developed because people with dementia live with an average of five other chronic diseases, which are often managed with medications. The systematic review that informed the criteria were published subsequently in 2018 andupdated in 2022.[236]
Over 40% of people with dementia report sleep problems. Approaches to treating these sleep problems include medications and non-pharmacological approaches.[237] The use of medications to alleviate sleep disturbances that people with dementia often experience has not been well researched, even for medications that are commonly prescribed.[238] In 2012 theAmerican Geriatrics Society recommended thatbenzodiazepines such asdiazepam, and non-benzodiazepinehypnotics, be avoided for people with dementia due to the risks of increased cognitive impairment and falls.[239] Benzodiazepines are also known to promotedelirium.[240] Additionally, little evidence supports the effectiveness of benzodiazepines in this population.[238][241] No clear evidence shows thatmelatonin orramelteon improves sleep for people with dementia due to Alzheimer's,[238] but it is used to treatREM sleep behavior disorder in dementia with Lewy bodies.[82] Limited evidence suggests that a low dose oftrazodone may improve sleep, however more research is needed.[238]
Non-pharmacological approaches have been suggested for treating sleep problems for those with dementia, however, there is no strong evidence or firm conclusions on the effectiveness of different types of interventions, especially for those who are living in an institutionalized setting such as a nursing home or long-term care home.[237]
As people age, they experience more health problems, and most health problems associated with aging carry a substantial burden of pain; therefore, between 25% and 50% of older adults experience persistent pain. Seniors with dementia experience the same prevalence of conditions likely to cause pain as seniors without dementia.[242] Pain is often overlooked in older adults and, when screened for, is often poorly assessed, especially among those with dementia, since they become incapable of informing others of their pain.[242][243] Beyond the issue of humane care, unrelieved pain has functional implications. Persistent pain can lead to decreased ambulation, depressed mood, sleep disturbances, impaired appetite, and exacerbation of cognitive impairment[243] and pain-related interference with activity is a factor contributing to falls in the elderly.[242][244]
Although persistent pain in people with dementia is difficult to communicate, diagnose, and treat, failure to address persistent pain has profound functional,psychosocial andquality of life implications for this vulnerable population. Health professionals often lack the skills and usually lack the time needed to recognize, accurately assess and adequately monitor pain in people with dementia.[242][245] Family members and friends can make a valuable contribution to the care of a person with dementia by learning to recognize and assess their pain. Educational resources and observational assessment tools are available.[242][246][247]
Persons with dementia may have difficulty eating. Whenever it is available as an option, the recommended response to eating problems is having a caretakerassist them.[219] A secondary option for people who cannot swallow effectively is to considergastrostomyfeeding tube placement as a way to give nutrition. However, in bringing comfort and maintaining functional status while lowering risk ofaspiration pneumonia and death, assistance with oral feeding is at least as good as tube feeding.[219][248] Tube-feeding is associated with agitation, increased use of physical and chemical restraints and worseningpressure ulcers. Tube feedings may cause fluid overload, diarrhea, abdominal pain, local complications, less human interaction and may increase the risk of aspiration.[249][250]
Benefits in those with advanced dementia has not been shown.[251] The risks of using tube feeding include agitation, rejection by the person (pulling out the tube, or otherwise physical or chemical immobilization to prevent them from doing this), or developing pressure ulcers.[219] The procedure is directly related to a 1% fatality rate[252] with a 3% major complication rate.[253] The percentage of people at end of life with dementia using feeding tubes in the US has dropped from 12% in 2000 to 6% as of 2014.[254][255]
The immediate and long-term effects of modifying the thickness of fluids for swallowing difficulties in people with dementia are not well known.[256] While thickening fluids may have an immediate positive effect on swallowing and improving oral intake, the long-term impact on the health of the person with dementia should also be considered.[256]
Exercise programs may improve the ability of people with dementia to perform daily activities, but the best type of exercise is still unclear.[257] Getting more exercise can slow the development of cognitive problems such as dementia, proving to reduce the risk of Alzheimer's disease by about 50%. A balance of strength exercise, to help muscles pump blood to the brain, and balance exercises are recommended for aging people. A suggested amount of about2+1⁄2 hours per week can reduce risks of cognitive decay as well as other health risks like falling.[258]
There is a lack of high-quality evidence to determine whetherassistive technology effectively supports people with dementia to manage memory issues.[259] Some of the specific things that are used today that helps with dementia today are: clocks, communication aids, electrical appliances the use monitoring, GPS location/ tracking devices, home care robots, in-home cameras, and medication management are just to name a few.[260] As the technology advances, virtual reality is also being explored as a powerful technology to elicit memories and to improve wellbeing.[261] Technology has the potential to be a valuable intervention for alleviating loneliness and promoting social connections, supported by available evidence.[262]
Given the progressive and terminal nature of dementia,palliative care can be helpful to patients and their caregivers by helping people with the disorder and their caregivers understand what to expect, deal with loss of physical and mental abilities, support the person's wishes and goals including surrogate decision making, and discuss wishes for or againstCPR andlife support.[266][267] Because the decline can be rapid, and because most people prefer to allow the person with dementia to make their own decisions, palliative care involvement before the late stages of dementia is recommended.[268][269] Further research is required to determine the appropriate palliative care interventions and how well they help people with advanced dementia.[181]
Remotely delivered interventions including support, training and information may reduce the burden for the informal caregiver and improve their depressive symptoms.[271] There is no certain evidence that they improve health-related quality of life.[271]
In several localities in Japan,digital surveillance may be made available to family members, if a dementia patient is prone to wandering and going missing.[272]
The number of cases of dementia worldwide in 2021 was estimated at 55 million, with close to 10 million new cases each year.[2] According to a report by theWorld Health Organization, "In 2021, Alzheimer’s disease and other forms of dementia ranked as the seventh leading cause of death, killing 1.8 million lives."[273] By 2050, the number of people living with dementia is estimated to be over 150 million globally.[274] Around 7% of people over the age of 65 have dementia, with slightly higher rates (up to 10% of those over 65) in places with relatively high life expectancy.[275] An estimated 58% of people with dementia are living in low and middle income countries.[276][277] The prevalence of dementia differs in different world regions, ranging from 4.7% in Central Europe to 8.7% in North Africa/Middle East; the prevalence in other regions is estimated to be between 5.6 and 7.6%.[276] The number of people living with dementia is estimated to double every 20 years. In 2016 dementia resulted in about 2.4 million deaths,[9] up from 0.8 million in 1990.[278] The genetic and environmental risk factors for dementia disorders vary by ethnicity.[279][280] For instance, Alzheimer's disease amongHispanic/Latino andAfrican American subjects exhibit lower risks associated with gene changes in theapolipoprotein E gene than do non-Hispanic white subjects.[281]
The annual incidence of dementia diagnosis is nearly 10 million worldwide.[181] Almost half of new dementia cases occur in Asia, followed by Europe (25%), the Americas (18%) and Africa (8%). The incidence of dementia increases exponentially with age, doubling with every 6.3-year increase in age.[276] Dementia affects 5% of the population older than 65 and 20–40% of those older than 85.[282] Rates are slightly higher in women than men at ages 65 and greater.[282] The disease trajectory is varied and the median time from diagnosis to death depends strongly on age at diagnosis, from 6.7 years for people diagnosed aged 60–69 to 1.9 years for people diagnosed at 90 or older.[181]
Dementia impacts not only individuals with dementia, but also their carers and the wider society. Among people aged 60 years and over, dementia is ranked the 9th most burdensome condition according to the 2010Global Burden of Disease (GBD) estimates. The global costs of dementia was around US$818 billion in 2015, a 35.4% increase from US$604 billion in 2010.[276]
A new 2024 study reveals that deaths from dementia in the U.S. have tripled in the past 21 years, rising from around 150,000 in 1999 to over 450,000 in 2020; the likelihood of dying from dementia increased across all demographic groups studied.[283]
About 3% of people between the ages of 65–74 have dementia, 19% between 75 and 84, and nearly half of those over 85 years of age. As more people are living longer, dementia is becoming more common.[284] For people of a specific age, however, it may be becoming less frequent in the developed world, due to a decrease in modifiable risk factors made possible by greater financial and educational resources. It is one of the most common causes of disability among the elderly but can develop before the age of 65 when it is known as early-onset dementia or presenile dementia.[285][286] Less than 1% of those with Alzheimer's have gene mutations that cause a much earlier development of the disease, around the age of 45, known asearly-onset Alzheimer's disease.[287] More than 95% of people with Alzheimer's disease have the sporadic form (late onset, 80–90 years of age).[287] Worldwide the cost of dementia in 2015 was put at US$818 billion. People with dementia are often physically or chemically restrained to a greater degree than necessary, raising issues of human rights.[2][288]Social stigma is commonly perceived by those with the condition, and also by their caregivers.[104]
Until the end of the 19th century, dementia was a much broader clinical concept. It included mental illness and any type of psychosocial incapacity, including reversible conditions.[289]Dementia at this time simply referred to anyone who had lost the ability to reason, and was applied equally to psychosis, "organic" diseases likesyphilis that destroy the brain, and to the dementia associated with old age, which was attributed to "hardening of the arteries".
A 19th-century drawing of a woman diagnosed with dementia
Dementia has been referred to in medical texts sinceantiquity. One of the earliest known allusions to dementia is attributed to the 7th-century BCGreek philosopherPythagoras, who divided the human lifespan into six distinct phases: 0–6 (infancy), 7–21 (adolescence), 22–49 (young adulthood), 50–62 (middle age), 63–79 (old age), and 80–death (advanced age). The last two he described as the "senium", a period of mental and physical decay, and that the final phase was when "the scene of mortal existence closes after a great length of time that very fortunately, few of the human species arrive at, where the mind is reduced to the imbecility of the first epoch of infancy".[290] In 550 BC, the Athenian statesman and poetSolon argued that the terms of a man's will might be invalidated if he exhibited loss of judgement due to advanced age.Chinese medical texts made allusions to the condition as well, and the characters for "dementia" translate literally to "foolish old person".[291]
Athenian philosophersAristotle andPlato discussed the mental decline that can come with old age and predicted that this affects everyone who becomes old and nothing can be done to stop this decline from taking place. Plato specifically talked about how the elderly should not be in positions that require responsibility because, "There is not much acumen of the mind that once carried them in their youth, those characteristics one would call judgement, imagination, power of reasoning, and memory. They see them gradually blunted by deterioration and can hardly fulfill their function."[292]
For comparison, the Roman statesmanCicero held a view much more in line with modern-day medical wisdom that loss of mental function was not inevitable in the elderly and "affected only those old men who were weak-willed". He spoke of how those who remained mentally active and eager to learn new things could stave off dementia. However, Cicero's views on aging, although progressive, were largely ignored in a world that would be dominated for centuries by Aristotle's medical writings. Physicians during the Roman Empire, such asGalen andCelsus, simply repeated the beliefs of Aristotle while adding few new contributions to medical knowledge.
Byzantine physicians sometimes wrote of dementia. It is recorded that at least seven emperors whose lifespans exceeded 70 years displayed signs of cognitive decline. InConstantinople, special hospitals housed those diagnosed with dementia or insanity, but these did not apply to the emperors, who were above the law and whose health conditions could not be publicly acknowledged.
Otherwise, little is recorded about dementia in Western medical texts for nearly 1700 years. One of the few references was the 13th-century friarRoger Bacon, who viewed old age as divine punishment fororiginal sin. Although he repeated existing Aristotelian beliefs that dementia was inevitable, he did make the progressive assertion that the brain was the center of memory and thought rather than the heart.
Poets, playwrights, and other writers made frequent allusions to the loss of mental function in old age.William Shakespeare notably mentions it in plays such asHamlet andKing Lear.
During the 19th century, doctors generally came to believe that elderly dementia was the result ofcerebral atherosclerosis, although opinions fluctuated between the idea that it was due to blockage of the major arteries supplying the brain or small strokes within the vessels of thecerebral cortex.
In 1907, Bavarian psychiatristAlois Alzheimer was the first to identify and describe the characteristics of progressive dementia in the brain of 51-year-oldAuguste Deter.[293] Deter had begun to behave uncharacteristically, including accusing her husband of adultery, neglecting household chores, exhibiting difficulties writing and engaging in conversations, heightened insomnia, and loss of directional sense.[294] At one point, Deter was reported to have "dragged a bed sheet outside, wandered around wildly, and cried for hours at midnight."[294] Alzheimer began treating Deter when she entered aFrankfurt mental hospital on November 25, 1901.[294] During her ongoing treatment, Deter and her husband struggled to afford the cost of the medical care, and Alzheimer agreed to continue her treatment in exchange for Deter's medical records and donation of her brain upon death.[294] Deter died on April 8, 1906, after succumbing tosepsis andpneumonia.[294] Alzheimer conducted the brain biopsy using theBielschowsky stain method, which was a new development at the time, and he observedsenile plaques,neurofibrillary tangles, and atherosclerotic alteration.[293] At the time, the consensus among medical doctors had been that senile plaques were generally found in older patients, and the occurrence of neurofibrillary tangles was an entirely new observation at the time.[294] Alzheimer presented his findings at the 37th psychiatry conference of southwestern Germany inTübingen on April 11, 1906; however, the information was poorly received by his peers.[294] By 1910, Alois Alzheimer's teacher,Emil Kraepelin, published a book in which he coined the term "Alzheimer's disease" in an attempt to acknowledge the importance of Alzheimer's discovery.[293][294]
By the 1960s, the link betweenneurodegenerative diseases and age-related cognitive decline had become more established. By the 1970s, the medical community maintained that vascular dementia was rarer than previously thought and Alzheimer's disease caused the vast majority of old age mental impairments. More recently however, it is believed that dementia is often a mixture of conditions.
In 1976, neurologistRobert Katzmann suggested a link between senile dementia and Alzheimer's disease.[295] Katzmann suggested that much of the senile dementia occurring (by definition) after the age of 65, was pathologically identical with Alzheimer's disease occurring in people under age 65 and therefore should not be treated differently.[296] Katzmann thus suggested that Alzheimer's disease, if taken to occur over age 65, is actually common, not rare, and was the fourth- or 5th-leading cause of death, even though rarely reported on death certificates in 1976.
A helpful finding was that although the incidence of Alzheimer's disease increased with age (from 5–10% of 75-year-olds to as many as 40–50% of 90-year-olds), no threshold was found by which age all persons developed it. This is shown by documented supercentenarians (people living to 110 or more) who experienced no substantial cognitive impairment. Some evidence suggests that dementia is most likely to develop between ages 80 and 84 and individuals who pass that point without being affected have a lower chance of developing it.[citation needed] Women account for a larger percentage of dementia cases than men.[297] This can be attributed in part to their longer overall lifespan and greater odds of attaining an age where the condition is likely to occur.[298]
Much like other diseases associated with aging, dementia was comparatively rare before the 20th century, because few people lived past 80. Conversely, syphilitic dementia was widespread in the developed world until it was largely eradicated by the use ofpenicillin afterWorld War II. With significant increases in life expectancy thereafter, the number of people over 65 started rapidly climbing. While elderly persons constituted an average of 3–5% of the population prior to 1945, by 2010 many countries reached 10–14% and in Germany and Japan, this figure exceeded 20%. Public awareness of Alzheimer's Disease greatly increased in 1994 when former US presidentRonald Reagan announced that he had been diagnosed with the condition.
In the 21st century,other types of dementia were differentiated from Alzheimer's disease and vascular dementias (the most common types). This differentiation is on the basis of pathological examination of brain tissues, by symptomatology, and by different patterns of brain metabolic activity in nuclear medical imaging tests such asSPECT andPET scans of the brain. The various forms have differing prognoses and differing epidemiologic risk factors. The main cause for many diseases, including Alzheimer's disease, remains unclear.[299]
Dementia in the elderly was once calledsenile dementia orsenility, and viewed as a normal and somewhat inevitable aspect ofaging.[300][301]
By 1913–20 the termdementia praecox was introduced to suggest the development of senile-type dementia at a younger age. Eventually the two terms fused, so that until 1952 physicians used the termsdementia praecox (precocious dementia) andschizophrenia interchangeably. Since then, science has determined that dementia and schizophrenia are two different disorders, though they share some similarities.[302] The termprecocious dementia for a mental illness suggested that a type of mental illness like schizophrenia (includingparanoia and decreased cognitive capacity) could be expected to arrive normally in all persons with greater age (seeparaphrenia). After about 1920, the beginning use ofdementia for what is now understood as schizophrenia and senile dementia helped limit the word's meaning to "permanent, irreversible mental deterioration". This began the change to the later use of the term. In recent studies, researchers have seen a connection between those diagnosed with schizophrenia and patients who are diagnosed with dementia, finding a positive correlation between the two diseases.[303]
The view that dementia must always be the result of a particular disease process led for a time to the proposed diagnosis of "senile dementia of the Alzheimer's type" (SDAT) in persons over the age of 65, with "Alzheimer's disease" diagnosed in persons younger than 65 who had the same pathology. Eventually, however, it was agreed that the age limit was artificial, and thatAlzheimer's disease was the appropriate term for persons with that particular brain pathology, regardless of age.
After 1952, mental illnesses including schizophrenia were removed from the category oforganic brain syndromes, and thus (by definition) removed from possible causes of "dementing illnesses" (dementias). At the same, however, the traditional cause of senile dementia – "hardening of the arteries" – now returned as a set of dementias of vascular cause (small strokes). These were now termedmulti-infarct dementias orvascular dementias.
The societal cost of dementia is high, especially for caregivers.[304] According to a UK-based study, almost two out of three carers of people with dementia feel lonely. Most of the carers in the study were family members or friends.[305][306]
As of 2015[update], the annual cost per Alzheimer's patient in the United States was around $19,144.36. The total costs for the nation is estimated to be about $167.74 billion. By 2030, it is predicted the annual socioeconomic cost will total to about $507 billion, and by 2050 that number is expected to reach $1.89 trillion. This steady increase will be seen not just within the United States but globally. Global estimates for the costs of dementia were $957.56 billion in 2015, but by 2050 the estimated global cost is $9.12 trillion.[307]
Many countries consider the care of people living with dementia a national priority and invest in resources and education to better inform health and social service workers, unpaid caregivers, relatives and members of the wider community. Several countries have authored national plans or strategies.[308][309] These plans recognize that people can live reasonably with dementia for years, as long as the right support and timely access to a diagnosis are available. Former British Prime MinisterDavid Cameron described dementia as a "national crisis", affecting 800,000 people in the United Kingdom.[310] In fact, dementia has become the leading cause of death for women in England.[311]
There, as with all mental disorders, people with dementia could potentially be a danger to themselves or others, they can be detained under theMental Health Act 1983 for assessment, care and treatment. This is a last resort, and is usually avoided by people with family or friends who can ensure care.
Some hospitals in Britain work to provide enriched and friendlier care. To make the hospital wards calmer and less overwhelming to residents, staff replaced the usual nurses' station with a collection of smaller desks, similar to a reception area. The incorporation of bright lighting helps increase positive mood and allow residents to see more easily.[312]
Driving with dementia can lead to injury or death. Doctors should advise appropriate testing on when to quit driving.[313] The United KingdomDVLA (Driver & Vehicle Licensing Agency) states that people with dementia who specifically have poor short-term memory, disorientation, or lack of insight or judgment are not allowed to drive, and in these instances the DVLA must be informed so that the driving license can be revoked. They acknowledge that in low-severity cases and those with an early diagnosis, drivers may be permitted to continue driving.
Many support networks are available to people with dementia and their families and caregivers. Charitable organizations aim to raise awareness and campaign for the rights of people living with dementia. Support and guidance are available on assessing testamentary capacity in people with dementia.[314]
In 2015, Atlantic Philanthropies announced a $177 million gift aimed at understanding and reducing dementia. The recipient was Global Brain Health Institute, a program co-led by theUniversity of California, San Francisco andTrinity College Dublin. This donation is the largest non-capital grant Atlantic has ever made, and the biggest philanthropic donation in Irish history.[315]
In October 2020,the Caretaker's last music release,Everywhere at the End of Time, was popularized byTikTok users for its depiction of the stages of dementia.[316] Caregivers were in favor of this phenomenon; Leyland Kirby, the creator of the record, echoed this sentiment, explaining it could cause empathy among a younger public.[317]
On November 2, 2020, Scottish billionaire SirTom Hunter donated £1 million to dementia charities, after watching a former music teacher with dementia, Paul Harvey, playing one of his own compositions on the piano in a viral video. The donation was announced to be split between the Alzheimer's Society and Music for Dementia.[318]
^Kosaka (2017) writes: "Dementia with Lewy bodies (DLB) is now well known to be the second most frequent dementia following Alzheimer disease (AD). Of all types of dementia, AD is known to account for about 50%, DLB about 20% and vascular dementia (VD) about 15%. Thus, AD, DLB, and VD are now considered to be the three major dementias."[68] The NINDS (2020) says that Lewy body dementia "is one of the most common causes of dementia, after Alzheimer's disease and vascular disease."[69] Hershey (2019) says, "DLB is the third most common of all the neurodegenerative diseases behind both Alzheimer's disease and Parkinson's disease".[70]
^abcCommission de la transparence (June 2012). "Drugs for Alzheimer's disease: best avoided. No therapeutic advantage" [Drugs for Alzheimer's disease: best avoided. No therapeutic advantage].Prescrire International.21 (128): 150.PMID22822592.
^Casselman B (May 31, 2024)."Alzheimer's Takes a Financial Toll Long Before Diagnosis, Study Finds".The New York Times. Archived fromthe original on June 30, 2024. RetrievedJuly 27, 2024.Credit scores among people who later develop dementia begin falling sharply long before their disease is formally identified. A year before diagnosis, these people were 17.2 percent more likely to be delinquent on their mortgage payments than before the onset of the disease, and 34.3 percent more likely to be delinquent on their credit card bills.
^Reisberg B, Ferris SH, de Leon MJ, Crook T (September 1982). "The Global Deterioration Scale for assessment of primary degenerative dementia".Am J Psychiatry.139 (9):1136–1139.doi:10.1037/t48466-000.PMID7114305.
^Reisberg B, Ferris SH, Franssen E (June 1985). "An ordinal functional assessment tool for Alzheimer's-type dementia".Hosp Community Psychiatry.36 (6):593–595.doi:10.1176/ps.36.6.593.PMID4007814.
^abBreton A, Casey D, Arnaoutoglou NA (February 2019). "Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta-analysis of diagnostic accuracy studies".International Journal of Geriatric Psychiatry.34 (2):233–242.doi:10.1002/gps.5016.PMID30370616.S2CID53097138.
^"Lewy body dementia: Hope through research".National Institute of Neurological Disorders and Stroke. US National Institutes of Health. January 10, 2020. RetrievedMarch 18, 2020.
^Abyadeh M, Gupta V, Chitranshi N, Gupta V, Wu Y, Saks D, et al. (April 2021). "Mitochondrial dysfunction in Alzheimer's disease – a proteomics perspective".Expert Review of Proteomics.18 (4):295–304.doi:10.1080/14789450.2021.1918550.PMID33874826.S2CID233310698.
^Jurek L, Herrmann M, Bonze M, et al. (March 1, 2018). "Behavioral and psychological symptoms in Lewy body disease: a review".Gériatrie et Psychologie Neuropsychiatrie du Vieillissement.16 (1):87–95.doi:10.1684/pnv.2018.0723.PMID29569570.
^Gray F, Adle-Biassette H, Chretien F, Lorin de la Grandmaison G, Force G, Keohane C (2001). "Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments".Clinical Neuropathology.20 (4):146–155.PMID11495003.
^abcNunes PT, Kipp BT, Reitz NL, Savage LM (2019). "Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction".Late Aging Associated Changes in Alcohol Sensitivity, Neurobehavioral Function, and Neuroinflammation. International Review of Neurobiology. Vol. 148. pp. 101–168.doi:10.1016/bs.irn.2019.09.002.ISBN978-0-12-817530-9.PMC7372724.PMID31733663.
^abcMakhlouf S, Messelmani M, Zaouali J, Mrissa R (2018). "Cognitive impairment in celiac disease and non-celiac gluten sensitivity: review of literature on the main cognitive impairments, the imaging and the effect of gluten free diet".Acta Neurol Belg (Review).118 (1):21–27.doi:10.1007/s13760-017-0870-z.PMID29247390.S2CID3943047.
^Aarsland D, Kurz MW (February 2010). "The epidemiology of dementia associated with Parkinson disease".Journal of the Neurological Sciences (Review).289 (1–2):18–22.doi:10.1016/j.jns.2009.08.034.PMID19733364.S2CID24541533.
^Caplan JP, Rabinowitz T (November 2010). "An approach to the patient with cognitive impairment: delirium and dementia".The Medical Clinics of North America.94 (6):1103–1116, ix.doi:10.1016/j.mcna.2010.08.004.PMID20951272.
^Gleason OC (March 2003)."Delirium".American Family Physician.67 (5):1027–1034.PMID12643363.Archived from the original on September 29, 2007.
^Worrall L, Hickson LM (2003). "Implications for theory, practice, and policy". In Worrall LE, Hickson LM (eds.).Communication disability in aging: from prevention to intervention. Clifton Park, NY: Delmar Learning. pp. 297–298.ISBN978-0-7693-0015-3.
^Boustani M, Peterson B, Hanson L, Harris R, Lohr KN (June 2003). "Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force".Annals of Internal Medicine.138 (11):927–937.doi:10.7326/0003-4819-138-11-200306030-00015.PMID12779304.S2CID20779164.
^Contador, I. et al. (2017) "Impact of literacy and years of education on the diagnosis of dementia:A population-based study,” Journal of Clinical and Experimental Neuropsychology, 39(2), pp. 112–119. Available at:https://doi.org/10.1080/13803395.2016.1204992.
^Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. (April 2005). "The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment".Journal of the American Geriatrics Society.53 (4):695–699.doi:10.1111/j.1532-5415.2005.53221.x.PMID15817019.S2CID9014589.
^Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL (July 2006). "Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation".Clinical Nuclear Medicine.31 (7):376–378.doi:10.1097/01.rlu.0000222736.81365.63.PMID16785801.S2CID39518497.
^Hubbard HI, Mamo SK, Hopper T (July 2018). "Dementia and Hearing Loss: Interrelationships and Treatment Considerations".Seminars in Speech and Language.39 (3):197–210.doi:10.1055/s-0038-1660779.PMID29933487.S2CID49383232.
^Fink HA, Jutkowitz E, McCarten JR, Hemmy LS, Butler M, Davila H, et al. (January 2018). "Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review".Annals of Internal Medicine.168 (1):39–51.doi:10.7326/M17-1529.PMID29255847.S2CID24193907.
^Carter CJ (February 2011). "Alzheimer's disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction".Neurochemistry International.58 (3):301–320.doi:10.1016/j.neuint.2010.12.003.PMID21167244.S2CID715832.
^Gibson, GE, Hirsch, JA, Fonzetti, P, et al. (2016) Vitamin B1 (thiamine) and dementia. Ann N Y Acad Sci 1367, 21–30
^Butterworth, RF (2003) Thiamin deficiency and brain disorders. Nutr Res Rev 16, 277–284.
^Hoffman, R. (2016). Thiamine deficiency in the Western diet and dementia risk. British Journal Of Nutrition, 116(1), 188–189.
^Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Lu H, et al. (November 2016). "Dietary Patterns and Risk of Dementia: a Systematic Review and Meta-Analysis of Cohort Studies".Molecular Neurobiology.53 (9):6144–6154.doi:10.1007/s12035-015-9516-4.OCLC6947867710.PMID26553347.S2CID8188716.
^Watt JA, Goodarzi Z, Veroniki AA, Nincic V, Khan PA, Ghassemi M, et al. (November 2019). "Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis".Annals of Internal Medicine.171 (9):633–642.doi:10.7326/M19-0993.PMID31610547.S2CID204699972.
^Vandepitte S, Van Den Noortgate N, Putman K, Verhaeghe S, Verdonck C, Annemans L (December 2016). "Effectiveness of respite care in supporting informal caregivers of persons with dementia: a systematic review".International Journal of Geriatric Psychiatry.31 (12):1277–1288.doi:10.1002/gps.4504.PMID27245986.S2CID3464912.
^Jeon YH, Li Z, Low LF, Chenoweth L, O'Connor D, Beattie E, Liu Z, Brodaty H (August 2015). "The clinical utility of the Cornell Scale for Depression in Dementia as a routine assessment in nursing homes".The American Journal of Geriatric Psychiatry.23 (8):784–793.doi:10.1016/j.jagp.2014.08.013.PMID25256214.
^Harper AE, Rouch S, Leland NE, Turner RL, Mansbach WE, Day CE, Terhorst L (April 2022). "A Systematic Review of Tools Assessing the Perspective of Caregivers of Residents With Dementia".Journal of Applied Gerontology.41 (4):1196–1208.doi:10.1177/07334648211028692.PMID34229505.S2CID235758241.
^Neal M, Barton Wright P (2003). "Validation therapy for dementia".The Cochrane Database of Systematic Reviews (3): CD001394.doi:10.1002/14651858.CD001394.PMID12917907.
^Woods B, Aguirre E, Spector AE, Orrell M (February 2012). "Cognitive stimulation to improve cognitive functioning in people with dementia".The Cochrane Database of Systematic Reviews.2 (2): CD005562.doi:10.1002/14651858.CD005562.pub2.PMID22336813.S2CID7086782.
^Weitzel T, Robinson S, Barnes MR, et al. (2011). "The special needs of the hospitalized patient with dementia".Medsurg Nursing.20 (1):13–18, quiz 19.PMID21446290.
^abRaj SE, Mackintosh S, Fryer C, Stanley M (January 1, 2021). "Home-Based Occupational Therapy for Adults With Dementia and Their Informal Caregivers: A Systematic Review".The American Journal of Occupational Therapy.75 (1): 7501205060p1–7501205060p27.doi:10.5014/ajot.2020.040782.PMID33399054.S2CID230618534.
^Wang K, Alan J, Page AT, Dimopoulos E, Etherton-Beer C (September 2021). "Anticholinergics and clinical outcomes amongst people with pre-existing dementia: A systematic review".Maturitas.151. Elsevier BV:1–14.doi:10.1016/j.maturitas.2021.06.004.PMID34446273.
^Seitz DP, Adunuri N, Gill SS, Gruneir A, Herrmann N, Rochon P (February 2011). "Antidepressants for agitation and psychosis in dementia".The Cochrane Database of Systematic Reviews (2): CD008191.doi:10.1002/14651858.CD008191.pub2.PMID21328305.
^Malouf R,Grimley Evans J (October 2008). "Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people".The Cochrane Database of Systematic Reviews (4): CD004514.doi:10.1002/14651858.CD004514.pub2.PMID18843658.
^Lolk A, Gulmann NC (October 2006). "[Psychopharmacological treatment of behavioral and psychological symptoms in dementia]".Ugeskrift for Laeger (in Danish).168 (40):3429–3432.PMID17032610.
^abcdeHadjistavropoulos T, Herr K, Turk DC, Fine PG, Dworkin RH, Helme R, Jackson K, Parmelee PA, Rudy TE, Lynn Beattie B, Chibnall JT, Craig KD, Ferrell B, Ferrell B, Fillingim RB, Gagliese L, Gallagher R, Gibson SJ, Harrison EL, Katz B, Keefe FJ, Lieber SJ, Lussier D, Schmader KE, Tait RC, Weiner DK, Williams J (January 2007). "An interdisciplinary expert consensus statement on assessment of pain in older persons".The Clinical Journal of Pain.23 (1 Suppl):S1 –S43.doi:10.1097/AJP.0b013e31802be869.PMID17179836.S2CID43777445.
^Brown C (2009). "Pain, aging and dementia: The crisis is looming, but are we ready?".British Journal of Occupational Therapy.72 (8):371–375.doi:10.1177/030802260907200808.S2CID73245194.
^Stolee P, Hillier LM, Esbaugh J, Bol N, McKellar L, Gauthier N (February 2005). "Instruments for the assessment of pain in older persons with cognitive impairment".Journal of the American Geriatrics Society.53 (2):319–326.doi:10.1111/j.1532-5415.2005.53121.x.PMID15673359.S2CID21006144.
Gillick MR, Volandes AE (June 2008). "The standard of caring: why do we still use feeding tubes in patients with advanced dementia?".Journal of the American Medical Directors Association.9 (5):364–367.doi:10.1016/j.jamda.2008.03.011.PMID18519120.
^Mitchell SL, Kiely DK, Lipsitz LA (February 1997). "The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment".Archives of Internal Medicine.157 (3):327–332.doi:10.1001/archinte.1997.00440240091014.PMID9040301.
^Lockett MA, Templeton ML, Byrne TK, Norcross ED (February 2002). "Percutaneous endoscopic gastrostomy complications in a tertiary-care center".The American Surgeon.68 (2):117–120.doi:10.1177/000313480206800202.PMID11842953.S2CID43796062.
^Finocchiaro C, Galletti R, Rovera G, Ferrari A, Todros L, Vuolo A, Balzola F (June 1997). "Percutaneous endoscopic gastrostomy: a long-term follow-up".Nutrition.13 (6):520–523.doi:10.1016/S0899-9007(97)00030-0.PMID9263232.
^Mitchell G, Agnelli J (October 2015). "Person-centred care for people with dementia: Kitwood reconsidered".Nursing Standard.30 (7):46–50.doi:10.7748/ns.30.7.46.s47.PMID26463810.
^abcdAlzheimer's Disease International (September 2015)."World Alzheimer Report 2015"(PDF).Archived(PDF) from the original on October 9, 2022. RetrievedOctober 30, 2018.
^Sabayan B, Wyman-Chick KA, Sedaghat S (February 2023). "The Burden of Dementia Spectrum Disorders and Associated Comorbid and Demographic Features".Clinics in Geriatric Medicine.39 (1):1–14.doi:10.1016/j.cger.2022.07.001.PMID36404023.S2CID253068389.
^Berchtold NC, Cotman CW (1998). "Evolution in the conceptu-alization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s".Neurobiol Aging.19 (3):173–189.doi:10.1016/s0197-4580(98)00052-9.PMID9661992.S2CID24808582.
^Xihua J (1989).Diagnosis and Treatment of Senile Dementia: Research Methods and Perspective. Madhav Books (P) Limited, a unit of Serials Publications. p. 38.ISBN93-80615-34-5.
^abcZilka, N., & Novak, M. (2006). The tangled story of Alois Alzheimer.Bratislavske lekarske listy,107(9–10), 343–345.
^"What is dementia?". Alzheimer's Association. RetrievedAugust 6, 2018.Dementia is often incorrectly referred to as "senility" or "senile dementia," which reflects the formerly widespread but incorrect belief that serious mental decline is a normal part of aging.
^Taylor DC."Dementia". MedicineNet. RetrievedAugust 6, 2018.Senile dementia ("senility") is a term that was once used to describe all dementias; this term is no longer used as a diagnosis.
^Jia J, Wei C, Chen S, Li F, Tang Y, Qin W, et al. (April 2018). "The cost of Alzheimer's disease in China and re-estimation of costs worldwide".Alzheimer's & Dementia.14 (4):483–491.doi:10.1016/j.jalz.2017.12.006.PMID29433981.S2CID46762069.
