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| Other names | 7β-hydroxyhyoscyamine |
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| ECHA InfoCard | 100.164.962 |
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| Formula | C17H23NO4 |
| Molar mass | 305.374 g·mol−1 |
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Anisodamine, also known as7β-hydroxyhyoscyamine, is a mAChRanticholinergic andα1 adrenergicreceptor antagonist used in the treatment of acutecirculatory shock inChina.[1] It is given orally or byinjection, as a racemic mixture (racanisodamine) or as a hydrobromide salt of the natural enantiometer.[2] Eye drops at 0.5% concentration for slowing the progression of myopia is also available in China.[3]
Anisodamine is anaturally occurringtropanealkaloid found in some plants of the familySolanaceae includingDatura.[4] Its Mandarin Chinese name山莨菪碱 is given afterAnisodus tanguticus (Chinese:山莨菪;pinyin:shān làng dàng).[5]
In rodents, anisodamine is more "selective" in its action compared to atropine. It poorly passes the blood-brain barrier and binds brain mAChR less tightly. In rodents, it exhibits weaker CNS effects,[6] causes lessmydriasis, but has approximately equal or slightly lower potency in blocking spasms and in reducing GI motility.[7] Chinese textbooks consider it to have a similar spectrum of effects on humans.[8] As a result, it (or rather, its synthetic racemic version) is widely used in China. It was added to China's national Essential Medicine List in 2012.[9]
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