Patients usually have no symptoms at all, with no bleeding, discomfort, orinflammation related to the lesions, which mostly affect the lower limbs.[3] Nonetheless, there have been sporadic cases of angioma serpiginosum in the face, hands, feet, andmucous membranes, among other places.[4][5] According to typical descriptions, angioma serpiginosum has anerythematous backdrop with a purple to coppery-red punctate look that clusters together in serpiginous or gyrate patterns.[3]
It is often observed that the illness progresses gradually, starting as little asymptomatic lesions that expand and coalesce with central clearing around the borders.[3] In addition, the lesions often cease growing throughout puberty after a brief period of initial growth during childhood and stay stable until adulthood.[6] Rarely, large areas are affected, and the symptoms appear later.[7] There have been reports of acral or zosteriform distribution cases.[8][9]
It is uncertain what specifically causes angioma serpiginosum. While some experts have suggested that angioma serpiginosum could be caused by pathophysiologic changes brought on by freezing temperatures, others have suggested that there might be a hereditary component involved.[3]
Skin biopsy is required for confirmation of an angioma serpiginosum diagnosis; however,diascopy anddermoscopy can be used to further examine the diagnosis.[3]
^Poenitz, Nina; Koenen, Wolfgang; Utikal, Jochen; Goerdt, Sergij (2006-07-18). "Angioma serpiginosum following the lines of Blaschko – an effective treatment with the IPL technology".JDDG: Journal der Deutschen Dermatologischen Gesellschaft.4 (8). Wiley:650–653.doi:10.1111/j.1610-0387.2006.06013.x.ISSN1610-0379.PMID16895567.S2CID39242042.
^Bishara, Michael; Jiaravuthisan, Michael; Weinstein, Miriam (2018-02-09). "A 13-Year-Old Presenting With Recurrent Angioma Serpiginosum".Journal of Cutaneous Medicine and Surgery.22 (5). SAGE Publications:511–513.doi:10.1177/1203475418758987.ISSN1203-4754.PMID29421924.S2CID46867928.
