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Androvax

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Vaccine

Pharmaceutical compound

Androvax
Combination of
Androstendione	Androstane steroid
Human serum albumin	Serum protein
Clinical data
Trade names	Androvax
Other names	Androstenedione:human serum albumin conjugate
AHFS/Drugs.com	Monograph
Legal status
Legal status	US: ℞-only
Identifiers
CAS Number	128280-53-5
ChemSpider	None

Androvax, also known asandrostenedione:human serum albumin conjugate, is animmunogen andvaccine againstandrostenedione that is used inveterinary medicine to increase theovulation rate and number oflambs born toewes.^[1]^[2]^[3] It is aconjugate ofandrostenedione andhuman serum albumin.^[1]^[3] The drug is marketed inNew Zealand.^[1]^[3]

Androvax producesimmunity against androstenedione, and the generation ofantibodies against androstenedione decreases circulating levels of androstenedione.^[1] In addition, since androstenedione is the majorprecursor ofestrogens, estrogen levels are decreased as well.^[1] This is thought to result in reducednegative feedback on thehypothalamic-pituitary-gonadal axis and increasedgonadotropin secretion, which in turn improvesfertility andfecundity.^[1]

References

[edit]

^^a ^b ^c ^d ^e ^fJindal SK, Sharma MC (2010).Biotechnology in Animal Health and Production. New India Publishing. pp. 77–.ISBN 978-93-80235-35-6.
^Reproductive Technologies in Farm Animals. CABI. 2004. pp. 206–.ISBN 978-0-85199-049-1.
^^a ^b ^c"Androvax Label"(PDF).Schering-Plough Animal Health Ltd. MSD Animal Health.

Androgens andantiandrogens

Androgens
(incl.AASTooltip anabolic–androgenic steroid)

ARTooltip Androgen receptoragonists

19-Nortestosterone derivatives:Bolandiol dipropionate
Nandrolone esters (e.g.,nandrolone decanoate,nandrolone phenylpropionate)
Norclostebol
Norclostebol acetate
Oxabolone cipionate (oxabolone cypionate)
Trenbolone acetate
Trenbolone hexahydrobenzylcarbonate (trenbolone cyclohexylmethylcarbonate)

17α-Alkylated dihydrotestosterone derivatives:Androisoxazole
Furazabol
Mebolazine (dimethazine)
Mestanolone
Oxandrolone
Oxymetholone
Stanozolol

17α-Alkylated 19-nortestosterone derivatives:Ethylestrenol
Mibolerone
Norethandrolone
Normethandrone (methylestrenolone, normethisterone)
Propetandrol (propethandrol)

17α-Vinyltestosterone derivatives:Norvinisterone (vinylnortestosterone)

17α-Ethynyltestosterone derivatives:Danazol
Gestrinone
Progestins (e.g.,ethisterone (ethynyltestosterone),levonorgestrel,norgestrel,norethisterone (norethindrone),lynestrenol,norgestrienone)
Tibolone

Progesterone derivatives:Medroxyprogesterone acetate

Progonadotropins

Antiestrogens (e.g.,tamoxifen,clomifene)
GnRH agonists (e.g.,GnRH (gonadorelin),leuprorelin)
Gonadotropins (e.g.,LHTooltip luteinizing hormone,hCGTooltip human chorionic gonadotropin)

Antiandrogens

ARTooltip Androgen receptorantagonists

Steroidogenesis
inhibitors

5α-Reductase	Alfatradiol Dutasteride Epristeride Finasteride Saw palmetto extract
Others	Abiraterone acetate +niraparib Aminoglutethimide Bifluranol Cyproterone acetate Flutamide Ketoconazole Nilutamide Seviteronel^† Spironolactone

Antigonadotropins

Others

Androstenedione immunogens:Androvax (androstenedione albumin)
Ovandrotone albumin (Fecundin)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

See also: Androgen receptor modulators; Estrogens and antiestrogens; Progestogens and antiprogestogens; List of androgens/anabolic steroids

Estrogens andantiestrogens

Estrogens

ERTooltip Estrogen receptor agonists

Progonadotropins

Antiandrogens (e.g.,bicalutamide)
GnRH agonists (e.g.,GnRH (gonadorelin),leuprorelin)
Gonadotropins (e.g.,FSHTooltip follicle-stimulating hormone,LHTooltip luteinizing hormone)

Antiestrogens

ERTooltip Estrogen receptor antagonists (incl.SERMsTooltip selective estrogen receptor modulators/SERDsTooltip selective estrogen receptor downregulators)	Acolbifene^† Anordrin Bazedoxifene Broparestrol Clomifene^# Cyclofenil Enclomifene^† Epitiostanol Lasofoxifene Mepitiostane Ormeloxifene Ospemifene Raloxifene Tamoxifen^# Toremifene Exclusively antagonistic:Elacestrant Fulvestrant Imlunestrant Noncompetitive inhibitors:Trilostane
Aromatase inhibitors	First-generation:Aminoglutethimide Testolactone Second-generation:Fadrozole Formestane Third-generation:Anastrozole Exemestane Letrozole
Antigonadotropins	Androgens/anabolic steroids (e.g.,testosterone,testosterone esters,nandrolone esters,oxandrolone,fluoxymesterone) D₂ receptor antagonists (prolactin releasers) (e.g.,domperidone,metoclopramide,risperidone,haloperidol,chlorpromazine,sulpiride) GnRH agonists (e.g.,leuprorelin,goserelin) GnRH antagonists (e.g.,cetrorelix,elagolix) Progestogens (e.g.,chlormadinone acetate,cyproterone acetate,gestonorone caproate,hydroxyprogesterone caproate,medroxyprogesterone acetate,megestrol acetate)
Others	Mixed mechanism of action:Danazol Gestrinone Androstenedione immunogens:Androvax (androstenedione albumin) Ovandrotone albumin (Fecundin)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

See also: Estrogen receptor modulators; Androgens and antiandrogens; Progestogens and antiprogestogens; List of estrogens

Artificial induction of immunity /Immunization:Vaccines,Vaccination,Infection,Inoculation (J07)

Development

Classes

Administration

Global:
US:

Vaccines

Bacterial	Anthrax Brucellosis Cholera^# Diphtheria^# Hib^# Leptospirosis Lyme disease^‡ Meningococcus^# MeNZB NmVac4-A/C/Y/W-135 Pertussis^# Plague Pneumococcal^# PCV PPSV Q fever Tetanus^# Tuberculosis BCG^# Typhoid^# Ty21a ViCPS Typhus combination: DPT/DTwP/DTaP Td/Tdap research: Clostridioides difficile Group B streptococcal disease Shigellosis
Viral	Adenovirus Chikungunya Ebola rVSV-ZEBOV Flu^# H1N1 (Pandemrix) H5N1 H5N8 LAIV Hantavirus Hepatitis A^# Hepatitis B^# Hepatitis E HPV^# Cervarix Gardasil Japanese encephalitis^# Measles^# Mpox Mumps^# Polio^# Sabin Salk Rabies^# Rotavirus^# Rubella^# SARS-CoV-2 Corbevax^† Bharat Biotech^† CanSino^† CoronaVac^† EpiVacCorona^† Janssen Kostaive Moderna Novavax Oxford–AstraZeneca Pfizer–BioNTech Sanofi–GSK^† Sinopharm BIBP^† Skycovione^† Sputnik V^† Valneva^† Respiratory syncytial virus (RSV) Smallpox Tick-borne encephalitis^# Varicella zoster Chicken pox^# Shingles Yellow fever^# combination: Hepatitis A and B MMR MMRV research: Cytomegalovirus Dengue^# Epstein–Barr virus Hepatitis C Herpes simplex HIV Zika
Protozoan	Malaria RTS,S research: Trypanosomiasis
Helminthiasis	research: Hookworm Schistosomiasis
Other	Androvax (androstenedione albumin) Cancer vaccines ALVAC-CEA BCG^# Hepatitis B^# HPV^# Cervarix Gardasil Prostvac NicVAX Ovandrotone albumin (Fecundin) TA-CD TA-NIC combination: DTaP-IPV/Hib DTaP-IPV-HepB DTwP-HepB-Hib Hexavalent vaccine