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| Formula | C19H26O |
| Molar mass | 270.416 g·mol−1 |
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Androstadienone, orandrosta-4,16-dien-3-one, is a16-androstene classendogenoussteroid that has been described as having potentpheromone-like activities in humans.[1] The compound issynthesized fromandrostadienol by3β-hydroxysteroid dehydrogenase, and can be converted intoandrostenone (a more potent and odorous pheromone) by5α-reductase, which can subsequently be converted into3α-androstenol or3β-androstenol (also more potent and odorous pheromones) by3-ketosteroid reductase.[2]
Androstadienone is related to theandrogensex hormones; however, androstadienone does not exhibit anyandrogenic oranabolic effects. Though it has been reported to significantly affect the mood ofheterosexual women andhomosexual men, it does not alter behavior overtly,[3][4][5][6] although it may have more subtle effects on attention.[7]
Androstadienone is commonly sold in male fragrances; it is purported to increase sexual attraction. Androstadienone, in picogram quantities, has been shown to have "significant reduction of nervousness, tension and other negative feeling states" in female subjects.[8]
