| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | s.c. injection only, premedication with H1 and H2 antihistamines and beta-receptor agonists for bronchodilation |
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| Pharmacokinetic data | |
| Eliminationhalf-life | 2.5 h |
| Excretion | renal: 90% |
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Ancestim is a recombinant methionyl humanstem cell factor, branded byAmgen as StemGen. It was developed by Amgen and sold to Biovitrium, nowSwedish Orphan Biovitrum, in December, 2008.[1]
It is a 166 amino acid protein produced byE. coli bacteria into which a gene has been inserted for soluble humanstem cell factor.[2] It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has anamino acid sequence that is identical to the natural sequence predicted from humanDNA sequence analysis, except for the addition of an N-terminal methionine retained after expression inE. coli. Because Ancestim is produced inE. coli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised powder for reconstitution and administration as a subcutaneous (SC) injection and is indicated for use in combination withfilgrastim for mobilizing peripheralhematopoietic stem cells for latertransplantation in certain cancer patients.[3]
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