 | |
| Names | |
|---|---|
| Preferred IUPAC name 4-Amino-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one[1] | |
| Other names solvapyrin A, aminoazophene, aminoantipyrene, aminoantipyrine, metapyrazone | |
| Identifiers | |
| |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
|
| ECHA InfoCard | 100.001.321 |
| UNII | |
| |
| |
| Properties | |
| C11H13N3O1[2] | |
| Molar mass | 203.24 g/mol |
| Density | 1.207g/cm3 |
| Melting point | 106 to 110 °C (223 to 230 °F; 379 to 383 K) |
| Boiling point | 309 °C (588 °F; 582 K) @760mmHg |
| Hazards | |
| Flash point | 140.7 °C (285.3 °F; 413.8 K) |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Ampyrone is ametabolite ofaminopyrine withanalgesic,anti-inflammatory, andantipyretic properties.[2] While the parentdrug, aminopyrine, has been discouraged due to the risk ofagranulocytosis,[3][4] ampyrone itself has significantly lower toxicity.[5] It is used as areagent forbiochemical reactions producingperoxides orphenols.[2] Ampyrone stimulateslivermicrosomes and is also used to measureextracellular water.[2]
By applying an ampyrone solution, scientists can make skin temporarily transparent (to red light); and e.g. see directly into the brain (of living young mice, when the skull is very thin, thus transparent, the solution doesn't have such an effect on it): "This opens a literal window to peek into the brain's development .. Not only can we image the structures of these neurons, but we can also image the neural activity over time in an animal model. In the future, this approach could enable us to look at how these circuits form during the development of an animal."[6][7]
| pyrazolones / pyrazolidines | |
|---|---|
| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
|
| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
 | Thisdrug article relating to themusculoskeletal system is astub. You can help Wikipedia byexpanding it. |
 | This article about aheterocyclic compound is astub. You can help Wikipedia byexpanding it. |
