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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Formula | C18H24N2O5S |
| Molar mass | 380.46 g·mol−1 |
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Amosulalol (INN) is anantihypertensive drug. It has much higheraffinity forα1-adrenergic receptors than forβ-adrenergic receptors.[1] It is not approved for use in theUnited States.
Guaiacol (1) reacts withethylene oxide to give 2-(2-methoxyphenoxy)ethanol (2).Halogenation withthionyl chloride converts the alcohol group to a chloride, (3), which is used toalkylatebenzylamine (4) to give thesecondary amine (5). This forms atertiary amine (7) when combined with 5-bromoacetyl-2-methylbenzenesulfonamide (6). The reduction of thecarbonyl group withsodium borohydride produces (8) andcatalytic hydrogenation removes thebenzyl group, yielding amosulalol.[2][3][4]
