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| Clinical data | |
|---|---|
| Trade names | Tenuate, Tepanil, Nobesine, others |
| Other names | Diethylpropion, Diethylcathinone |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682037 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Eliminationhalf-life | 4–6 hours (metabolites)[7] |
| Excretion | Urine (>75%)[7] |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.001.836 |
| Chemical and physical data | |
| Formula | C13H19NO |
| Molar mass | 205.301 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Amfepramone, also known asdiethylpropion, is astimulant drug of thephenethylamine,amphetamine, andcathinoneclasses that is used as anappetite suppressant.[8][9] It is used in the short-term management ofobesity, along with dietary and lifestyle changes.[8] Amfepramone has a similar chemical structure to the antidepressant andsmoking cessation aidbupropion (previously called amfebutamone), which has also been developed as a weight-loss medicine when in a combination product withnaltrexone.[10]
Amfepramone itself lacks anyaffinity for themonoamine transporters and instead functions as aprodrug toethcathinone.[11] Ethcathinone (and therefore amfepramone as well) is a very weakdopaminergic andserotonergic, and is approximately 10× and 20× stronger onnorepinephrine in comparison, respectively.[11]
Amfepramone can be synthesized frompropiophenone bybromination, followed by reaction withdiethylamine.[12][13]
Another medically utilized name is diethylpropion (British Approved Name (BAN) andAustralian Approved Name (AAN)). Chemical names include: α-methyl-β-keto-N,N-diethylphenethylamine,N,N-diethyl-β-ketoamphetamine andN,N-diethylcathinone.Brand names include: Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil and Tenuate.
Amfepramone is classified as aSchedule IVcontrolled substance in the United States. In the UK amfepramone is a class C drug[14] and as a medicine, it is a Schedule 3 Controlled Drug which requires safe custody.
As of June 2022, the safety committee of theEuropean Medicines Agency (EMA) recommends the withdrawal of marketing authorizations for amfepramone.[15][6]
The authors of several studies of amfepramone claim that the substance has a relatively low potential for causing addiction in users.[16][17][4][18]
