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Alpha-1D adrenergic receptor

From Wikipedia, the free encyclopedia
Protein-coding gene in humans

ADRA1D
Identifiers
AliasesADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, adrenoceptor alpha 1D
External IDsOMIM:104219;MGI:106673;HomoloGene:551;GeneCards:ADRA1D;OMA:ADRA1D - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ADRA1D
Genomic location for ADRA1D
Band20p13Start4,220,630bp[1]
End4,249,287bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ADRA1D
Genomic location for ADRA1D
Band2 F1|2 63.5 cMStart131,387,770bp[2]
End131,404,203bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • Descending thoracic aorta

  • ascending aorta

  • canal of the cervix

  • ectocervix

  • stromal cell of endometrium

  • prefrontal cortex

  • lateral nuclear group of thalamus

  • tibial nerve

  • gastric mucosa
Top expressed in
  • hippocampus proper

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • olfactory bulb

  • superior frontal gyrus

  • white adipose tissue

  • adrenal gland

  • embryo

  • cerebellar cortex

  • embryo
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

146

11550

Ensembl

ENSG00000171873

ENSMUSG00000027335

UniProt

P25100

P97714

RefSeq (mRNA)

NM_000678

NM_013460

RefSeq (protein)

NP_000669
NP_000669.1

NP_038488

Location (UCSC)Chr 20: 4.22 – 4.25 MbChr 2: 131.39 – 131.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thealpha-1D adrenergic receptor1D adrenoreceptor), also known asADRA1D, is analpha-1 adrenergic receptor, and also denotes the humangene encoding it.[5]

Receptor

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There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

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This gene encodes alpha-1D-adrenergic receptor. Similar toalpha-1B-adrenergic receptor gene, this gene comprises 2exons and a singleintron that interrupts the coding region.[5]

Ligands

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Manyα1 receptor ligands are non-selective for receptor subtypes.

Antagonists

See also

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References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000171873Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000027335Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ab"Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor".
  6. ^Buckner SA, Milicic I, Daza A, Lynch JJ, Kolasa T, Nakane M, et al. (December 2001). "A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity".European Journal of Pharmacology.433 (1):123–127.doi:10.1016/s0014-2999(01)01519-9.PMID 11755142.
  7. ^Cleary L, Murad K, Bexis S, Docherty JR (October 2005). "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist".Autonomic & Autacoid Pharmacology.25 (4):135–141.doi:10.1111/j.1474-8673.2005.00342.x.PMID 16176444.
  8. ^Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Muramatsu I, et al. (June 2002). "(+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors".European Journal of Pharmacology.445 (1–2):21–29.doi:10.1016/s0014-2999(02)01601-1.PMID 12065190.
  9. ^abProudman RG, Pupo AS, Baker JG (August 2020)."The affinity and selectivity of α-adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D-adrenoceptors".Pharmacology Research & Perspectives.8 (4): e00602.doi:10.1002/prp2.602.PMC 7327383.PMID 32608144.

Further reading

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External links

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