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Aleph-4

From Wikipedia, the free encyclopedia
Pharmaceutical compound
Aleph-4
Clinical data
Other namesALEPH-4; 4-Isopropylthio-2,5-dimethoxyamphetamine; 2,5-Dimethoxy-4-isopropylthioamphetamine; 4-iPrS-DMA
Routes of
administration
Oral[1]
Drug classSerotonergic psychedelic;Hallucinogen
ATC code
  • None
Pharmacokinetic data
Duration of action12–20 hours[1]
Identifiers
  • 1-(2,5-dimethoxy-4-propan-2-ylsulfanylphenyl)propan-2-amine
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC14H23NO2S
Molar mass269.40 g·mol−1
3D model (JSmol)
  • CC(C)SC1=C(C=C(C(=C1)OC)CC(C)N)OC
  • InChI=1S/C14H23NO2S/c1-9(2)18-14-8-12(16-4)11(6-10(3)15)7-13(14)17-5/h7-10H,6,15H2,1-5H3
  • Key:BCWCXWKCQMBFBQ-UHFFFAOYSA-N

Aleph-4, orALEPH-4, also known as4-isopropylthio-2,5-dimethoxyamphetamine, is apsychedelic drug of thephenethylamine,amphetamine, andDOx families.[1] It is one of theAleph series of compounds.[1] In his bookPiHKAL (Phenethylamines I Have Known and Loved),Alexander Shulgin lists Aleph-4's dose as 7 to 12 mgorally and itsduration as 12 to 20 hours.[1] The effects of Aleph-4 have been reported to includeclosed-eyeimagery, enhancedvisual appreciation,emotional changes, andphysicalside effects andtoxicity indications, among others.[1] One of the reports remarked that it was "one of the most profound and deep learning experiences" they had had.[1] However, Shulgin was unwilling to push the dose higher than 12 mg due to toxicity concerns.[1] Thechemical synthesis of Aleph-4 has been described.[1] Aleph-4 was first described in thescientific literature by Shulgin,David E. Nichols,Peyton Jacob III, and other colleagues in 1978.[2] Subsequently, it was described in greater detail by Shulgin inPiHKAL in 1991.[1] The drug was encountered as a noveldesigner drug inJapan in 2009.[3][4]

See also

[edit]

References

[edit]
  1. ^abcdefghijShulgin, Alexander;Shulgin, Ann (September 1991).PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press.ISBN 0-9630096-0-5.OCLC 25627628.https://erowid.org/library/books_online/pihkal/pihkal005.shtml
  2. ^Braun U, Braun G, Jacob P, Nichols DE, Shulgin AT (1978)."Mescaline Analogs: Substitutions at the 4-Position"(PDF). In Barnett G, Trsic M, Willette RE (eds.).QuaSAR: Quantitative Structure Activity Relationships Of Analgesics, Narcotic Antagonists, And Hallucinogens(PDF). National Institute on Drug Abuse Research Monograph Series. Vol. 22. National Institute on Drug Abuse. pp. 27–37.PMID 101882.
  3. ^Suzuki, J., Moriyasu, T., Nagashima, M., Kanai, C., Shimizu, M., Hamano, T., & Nagayama, T. (2010). Analysis of uncontrolled drugs purchased in fiscal year 2009. Ann RepTokyo Metrop Inst Public Health [Japanese: Tōkyō-to Kenkō Anzen Kenkyū Sentā Kenkyū Nenpō], 61, 163–172.https://isomerdesign.com/bitnest/external/TokyoMetr.Inst.PH/61.163
  4. ^Uchiyama N, Miyazawa N, Kawamura M, Kikura-Hanajiri R, Goda Y (February 2010). "2008年度買い上げ違法ドラッグ製品から検出された新規流通デザイナードラッグの同定" [Analysis of newly distributed designer drugs detected in the products purchased in fiscal year 2008].Yakugaku Zasshi (in Japanese).130 (2):263–70.doi:10.1248/yakushi.130.263.PMID 20118651.

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