He was a student of theSpartak Moscow academy and was considered one of their most talented youngsters. He was a regular in the first team underNevio Scala but whenAleksandrs Starkovs came he lost his place in the first team. Spartak Moscow then purchasedVladimir Bystrov, and in the summer of 2005 Samedov left forLokomotiv Moscow for €3.4 million. However, Samedov failed to succeed in Loko, and in 2008 joinedFC Moscow. Having shown great progress under direction ofMiodrag Božović, he chose to become part of a bigger club and went toDynamo Moscow duringthe 2009–10 winter transfer period. On 27 June 2012, Samedov moved to Lokomotiv, where he played earlier. According to the source close to the club, Lokomotiv paid about 8.2 million € for his services.
During his second spell at Lokomotiv, Samedov established himself as starting XI fixture at right wing. In May 2013, when he added some goals to his usual good amount of assistances, he managed to win monthly poll among Loko fans in the social networks for the best player of the month.[7] He won this poll for the second time in April 2014.[8] After the end of 2013–14 season, club organized new poll among Loko fans in the social networks to name the best player of the season. The award went to Samedov with 32.3 percent of votes.[9]
On 16 January 2017, he returned toFC Spartak Moscow, winning theRussian Premier League title at the end of the season.[10] He was released from his Spartak contract by mutual consent on 5 January 2019.[11]
At international level Samedov has played for theRussia U-21s. He was called up to theRussia national football team in late September 2011 for the first time. On 7 October 2011, Samedov made his debut for the senior national team of Russia after coming on as a last-minute substitute forAlan Dzagoev in the 1–0 away win againstSlovakia in aEuro 2012 qualifier.
On 11 May 2018, he was included in Russia's extended2018 FIFA World Cup squad.[16] On 3 June 2018, he was included in the finalized World Cup squad.[17] He started Russia's every game in the World Cup, but was substituted in the second half in 3 out of 5, including both knock-out stage games.
Following Russia's 2018 FIFA World Cup quarterfinal loss toCroatia, he announced his retirement from the national team.[18]