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Aldehyde dehydrogenase 9 family, member A1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
ALDH9A1
Identifiers
AliasesALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1, TMABA-DH, TMABALDH
External IDsOMIM:602733;MGI:1861622;HomoloGene:55483;GeneCards:ALDH9A1;OMA:ALDH9A1 - orthologs
EC number1.2.1.3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ALDH9A1
Genomic location for ALDH9A1
Band1q24.1Start165,662,216bp[1]
End165,698,562bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ALDH9A1
Genomic location for ALDH9A1
Band1|1 H2.3Start167,177,560bp[2]
End167,196,101bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • salivary gland

  • minor salivary glands

  • mucosa of esophagus

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • liver

  • corpus callosum
Top expressed in
  • left lobe of liver

  • retinal pigment epithelium

  • Paneth cell

  • crypt of lieberkuhn of small intestine

  • human kidney

  • migratory enteric neural crest cell

  • ciliary body

  • jejunum

  • ileum

  • decidua
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

223

56752

Ensembl

ENSG00000143149

ENSMUSG00000026687

UniProt

P49189

Q9JLJ2

RefSeq (mRNA)

NM_000696
NM_001365774

NM_019993

RefSeq (protein)

NP_000687
NP_001352703

NP_064377
NP_001389759
NP_001389768
NP_001389769
NP_001389773

NP_001389774
NP_001389775
NP_001392024

Location (UCSC)Chr 1: 165.66 – 165.7 MbChr 1: 167.18 – 167.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

4-trimethylaminobutyraldehyde dehydrogenase is anenzyme that in humans is encoded by theALDH9A1gene.[5][6][7]

Function

[edit]

This protein belongs to thealdehyde dehydrogenase family of proteins. It has a high activity for oxidation ofgamma-aminobutyraldehyde (GABAL) and other amino aldehydes. The enzyme catalyzes the dehydrogenation of GABAL togamma-aminobutyric acid (GABA). This isozyme is atetramer of identical 54-kD subunits.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000143149 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000026687 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde".Human Genetics.93 (2):211–2.doi:10.1007/bf00210615.PMID 8112751.S2CID 26773065.
  6. ^Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression".Genomics.34 (3):376–80.doi:10.1006/geno.1996.0300.PMID 8786138.
  7. ^ab"Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

External links

[edit]

Further reading

[edit]


Family 1
Family 2 (mitochondrial)
Family 3
Other
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