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| Clinical data | |
|---|---|
| Trade names | Aclovate |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604021 |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 3% systemically (topical) |
| Metabolism | Hepatic |
| Onset of action | Eczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days[1] |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
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| UNII | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C22H29ClO5 |
| Molar mass | 408.92 g·mol−1 |
| 3D model (JSmol) | |
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Alclometasone is a syntheticcorticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.[2][3]
Theprodrugalclometasone dipropionate was originally marketed under the brand nameAclovate byGlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available.
Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:
Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
Adverse reactions (sometimes, less than 1-2% cases) include:
Alclometasone induces the production of lipocortins, formally known asannexins, which inhibitphospholipase A2 – the enzyme responsible for the synthesis ofarachidonic acid. Without the oxidation of arachidonic acid,eicosanoids, such asprostaglandins,thromboxanes, andleukotrienes, can't be produced.
Alclometasone also inhibits the release of pro-inflammatory mediators from leukocytes (e.g.,cytokines,histamine, leukotrienes,serotonin).
Alclometasone as Aclovate is supplied in: