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Afurolol

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Chemical compound

Pharmaceutical compound

Afurolol
Clinical data

ATC code	none
Identifiers
IUPAC name 7-[3-(tert-Butylamino)-2-hydroxy-propoxy]-3H-isobenzofuran-1-one
CAS Number	65776-67-2^N
PubChemCID	176877
ChemSpider	154050^Y
UNII	WQ1WRV49R9
ChEMBL	ChEMBL1742435^N
CompTox Dashboard(EPA)	DTXSID70867182
Chemical and physical data
Formula	C₁₅H₂₁NO₄
Molar mass	279.336 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1OCc2cccc(OCC(O)CNC(C)(C)C)c12
InChI InChI=1S/C15H21NO4/c1-15(2,3)16-7-11(17)9-19-12-6-4-5-10-8-20-14(18)13(10)12/h4-6,11,16-17H,7-9H2,1-3H3^Y Key:NFXPPCYKSAAUMQ-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Alfurolol is abeta blocker.^[1]^[2]

^"The Use of Common Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances: Alphabetical list of stems together with corresponding INNs". Archived fromthe original on March 7, 2012.
^Narimatsu S, Takemi C, Kuramoto S, Tsuzuki D, Hichiya H, Tamagake K, Yamamoto S (May 2003). "Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s".Chirality.15 (4):333–9.doi:10.1002/chir.10212.PMID 12666241.

Central

α₂-Adrenergic receptor agonists	Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	Pargyline^‡
VMAT inhibitors	Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	Metirosine

Direct

α₁-Adrenergic receptor blockers	Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	Phentolamine

Serotonin receptor antagonists	Ketanserin Lidanserin
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)	dual (Aprocitentan,Bosentan,Macitentan (+tadalafil),Riociguat) selective (Ambrisentan (+tadalafil),Sitaxentan,Sotatercept)