Being a first team regular in 2010, Mehmedi established himself as a physical striker, excellent in the box as well as having a good turn of pace, he was also technically great.[4] During his time with Zürich, Mehmedi scored nineteen goals and provided nine assists.
In the January transfer window in 2012, Mehmedi moved toDynamo Kyiv.
On 11 July 2013, Mehmedi moved to SC Freiburg.[5] Freiburg's acting sporting director Klemens Hartenbach stated that he was "delighted" the transfer went through. Hartenbach stated "He's a very versatile attacking player who understands the game and has already proven he can play at the highest level".[5] On 26 May 2014, Freiburg decided to buy Mehmedi for a reported €6 million after having a good season, scoring 12 goals in 32 games during his loan spell with the Bundesliga side.[6]
On 14 January 2022, Mehmedi signed a 2.5-year contract with Turkish clubAntalyaspor.[9]
At the end of the2022–23 season, the forward terminated his contract with the club by mutual consent;[10] on 30 August 2023, he publicly announced his retirement from professional football, citing his desire to spend more time with his family and pursue a coaching career as the main reasons behind his decision.[10][11]
Mehmedi was a crucial member of the Swiss U-21 side in the2011 UEFA European Under-21 Football Championship.[4] Mehmedi received the silver boot with three goals in the tournament and was selected in the UEFA Euro U-21 2011 Team of the Tournament.
Mehmedi made his debut for theSwiss national team againstEngland, in aUEFA Euro 2012 qualifying match, coming on as a substitute. Mehmedi scored his first goal for Switzerland in his side's 5–3 win overGermany. The Swiss national side had not beaten the Germans since 1956.[13]
Two years to the day after he scored in the 2014 World Cup against Ecuador,[15] Mehmedi scored Switzerland's equaliser in their 1–1 group-stage draw againstRomania inUEFA Euro 2016.[16][17]
Following his participation in Switzerland'sUEFA Euro 2020 campaign, in which they reached the quarter-finals for the first time, Mehmedi officially announced his retirement from the national side on 16 July 2021.[18]
Just three months after retiring as an active footballer, he joinedFC Schaffhausen as their new sporting director on 5 December 2023.[19] His mission to secure the team's place in theSwiss Challenge League was successful. Despite this, he requested a mutual termination of his contract on 27 May 2024, just six months after his appointment,[20] as he could not agree with the board's proposed budget reductions.
In 2016, Mehmedi and his father arranged to build a news house for an impoverished family inPadalište, saying: "You know, building a house is not cheap, but I appreciate what I have, and I want others to feel fine as well."[21]