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Acetryptine

From Wikipedia, the free encyclopedia
Drug
Pharmaceutical compound
Acetryptine
Clinical data
Other namesW-2965-A; 5-Acetyltryptamine; 5-Acetyl-3-(2-aminoethyl)indole;
Identifiers
  • 1-[3-(2-Aminoethyl)-1H-indol-5-yl]ethanone
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC12H14N2O
Molar mass202.257 g·mol−1
3D model (JSmol)
  • CC(=O)C1=CC2=C(C=C1)NC=C2CCN
  • InChI=1S/C12H14N2O/c1-8(15)9-2-3-12-11(6-9)10(4-5-13)7-14-12/h2-3,6-7,14H,4-5,13H2,1H3
  • Key:RAUGYAOLAMRLLZ-UHFFFAOYSA-N

Acetryptine (INN) (developmental code nameW-2965-A), also known as5-acetyltryptamine (5-AT),[1] is adrug described as anantihypertensive agent which was never marketed.[2] Structurally, acetryptine is asubstituted tryptamine, and is closely related to other substituted tryptamines likeserotonin (5-hydroxytryptamine).[2] It was developed in the early 1960s.[2][1] Thebinding of acetryptine toserotonin receptors does not seem to have been well-investigated, although it was assessed at the5-HT1A and5-HT1D receptors and found to bind to them with highaffinity.[3] The drug may also act as amonoamine oxidase inhibitor (MAOI); specifically, as aninhibitor ofMAO-A.[4][5]

See also

[edit]

References

[edit]
  1. ^abHARTIGAN JM, PHILLIPS GE (1963). "Tissue distribution and metabolism of 5-acetyltryptamine in the mouse".Biochem. Pharmacol.12 (6):585–8.doi:10.1016/0006-2952(63)90136-9.PMID 13953098.
  2. ^abcJ. Elks (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 6–.ISBN 978-1-4757-2085-3.
  3. ^Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C (1996). "Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors".J. Med. Chem.39 (1):314–22.doi:10.1021/jm950498t.PMID 8568822.
  4. ^Veselovsky AV, Medvedev AE, Tikhonova OV, Skvortsov VS, Ivanov AS (2000). "Modeling of substrate-binding region of the active site of monoamine oxidase A".Biochemistry Mosc.65 (8):910–6.PMID 11002183.
  5. ^Ramsay RR, Gravestock MB (2003). "Monoamine oxidases: to inhibit or not to inhibit".Mini Rev Med Chem.3 (2):129–36.doi:10.2174/1389557033405287.PMID 12570845.
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Tryptamines
N-Acetyltryptamines
α-Alkyltryptamines
Triptans
Cyclized tryptamines
Isotryptamines
Related compounds


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