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| Clinical data | |
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| MedlinePlus | a699015 |
| Routes of administration | By mouth |
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| Chemical and physical data | |
| Formula | C25H34N6O3 |
| Molar mass | 466.586 g·mol−1 |
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Acetildenafil (hongdenafil) is a syntheticdrug which acts as aphosphodiesterase inhibitor.[1] It is ananalog ofsildenafil (Viagra)[2] which has been detected in numerous different brands of "herbalaphrodisiac" products sold inconvenience stores that claim to boost libido and alleviateerectile dysfunction.[3]
A range of designer analogs of licensedPDE5 inhibitors such as sildenafil andvardenafil have been detected in recent years in over-the-counter herbal aphrodisiac products,[4][5][6][7] in an apparent attempt to circumvent both the legal restrictions on sale of erectile dysfunction drugs, which areprescription-only medicines in most Western countries, and thepatent protection which allows sale of these drugs by competitors only with permission from the patent holders (typically, under a license from the inventors) and to introduceefficacy into otherwise ineffective herbal products. These compounds have been demonstrated to display PDE5 inhibitory activityin vitro and presumably have similar effects when consumed, but have undergone no formal testing in either humans or animals, and as such may represent significant health risks to consumers of these products due to their unknown safety profile.[3][8] Attempts to ban such ingredients have not been successful for the most part, many jurisdictions having laws restricting chemical analogs but only those ofnarcotics anddoping agents. However, at least one court case has resulted in a product being taken off the market.[9]
