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Accelerated phase chronic myelogenous leukemia

From Wikipedia, the free encyclopedia
Medical condition
Accelerated phase chronic myelogenous leukemia
SpecialtyHematology andoncology

Accelerated phase chronic myelogenous leukemia is a phase ofchronic myelogenous leukemia in which the disease is progressing.[1]

Symptoms

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Common symptoms includefever,bone pain, andswollen spleen.[2]

Treatment

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Patients treated withimatinib,dasatinib, andnilotinib have shown meaningful rates of hematologic and cytogenetic response.[3]

Prognosis

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Prognosis is very poor once chronic myelogenous leukemia reaches the accelerated phase; it behaves similarly toacute myeloid leukemia.

References

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  1. ^Moshe Talpaz (2002). "Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study".Blood.99 (6):1928–1937.doi:10.1182/blood.v99.6.1928.PMID 11877262.S2CID 29480569.
  2. ^"Chronic myelogenous leukemia (CML)".
  3. ^Shah, NP (Mar 2008). "Advanced CML: therapeutic options for patients in accelerated and blast phases".Journal of the National Comprehensive Cancer Network. 6 Suppl 2:S31 –S36.PMID 18397679.

External links

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Classification
CFU-GM/
and othergranulocytes
CFU-GM
Myelocyte
AML
MP
Monocyte
AML
CML
Myelomonocyte
AML
MD-MP
Other
CFU-Baso
AML
CFU-Eos
AML
MP
MEP
CFU-Meg
MP
CFU-E
AML
MP
MD
CFU-Mast
Mastocytoma
Mastocytosis
Systemic mastocytosis
Multiple/unknown
AML
MP
Stub icon

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